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Tchem
RARRES3
Retinoic acid receptor responder protein 3

Protein Summary
Description
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable. Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255688
  • ENSP00000255688
  • ENSG00000133321
  • ENST00000439013
  • ENSP00000402943

Symbol
  • RIG1
  • TIG3
  • RIG1
  • TIG3
  • HRSL4
  • HRASLS4
  • PLAAT-4
  • RARRES3
  • PLA1/2-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
tissue
0.6
cell type or tissue
0.58
disease perturbation
0.56
small molecule perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.26   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.26   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (10)
Protein-Protein Interactions (17)
CRABP2
Tchem
Novelty:  0.0050363
Score:  0.717
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.662
Data Source:  STRINGDB
RARG
Tclin
Family:  NR
Novelty:  0.00667159
Score:  0.644
Data Source:  STRINGDB
RARB
Tclin
Family:  NR
Novelty:  0.00257427
Score:  0.62
Data Source:  STRINGDB
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
Score:  0.541
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.47
Data Source:  STRINGDB
SMYD5
Tbio
Family:  Epigenetic
Novelty:  0.11591101
Score:  0.466
Data Source:  STRINGDB
APOL3
Tbio
Novelty:  0.07656444
Score:  0.452
Data Source:  STRINGDB
GPRC5A
Tbio
Family:  GPCR
Novelty:  0.02060511
Score:  0.447
Data Source:  STRINGDB
UBE2L6
Tbio
Novelty:  0.03471633
Score:  0.436
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Acyl chain remodelling of PE (R-HSA-1482839)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PE
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PE
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
1
1
53.2
urate measurement
1
1
2
49.3
tri-iodothyronine/thyroxine ratio measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
53.2
urate measurement
2
49.3
tri-iodothyronine/thyroxine ratio measurement
1
1.8
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinoic acid receptor responder 3
VGNC:10184
451277
Dog
retinoic acid receptor responder 3
VGNC:45356
483772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinoic acid receptor responder 3
Dog
retinoic acid receptor responder 3
Publication Statistics
PubMed Score 82.26
PubMed score by year
PubTator Score 106.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title