RARRES3
Retinoic acid receptor responder protein 3
Protein Summary
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable. Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
- ENST00000255688
- ENSP00000255688
- ENSG00000133321
- ENST00000439013
- ENSP00000402943
- RIG1
- TIG3
- RIG1
- TIG3
- HRSL4
- HRASLS4
- PLAAT-4
- RARRES3
- PLA1/2-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.85 | ||
tissue | 0.6 | ||
cell type or tissue | 0.58 | ||
disease perturbation | 0.56 | ||
small molecule perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.26 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 217 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.26 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 217 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (10)
Protein-Protein Interactions (17)
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acyl chain remodelling of PE | ||||
Reactome | Glycerophospholipid biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Phospholipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acyl chain remodelling of PE | ||||
Glycerophospholipid biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Phospholipid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
uric acid measurement | 1 | 1 | 1 | 53.2 | |||||
urate measurement | 1 | 1 | 2 | 49.3 | |||||
tri-iodothyronine/thyroxine ratio measurement | 1 | 1 | 1 | 1.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
uric acid measurement | 1 | 53.2 | |||||
urate measurement | 2 | 49.3 | |||||
tri-iodothyronine/thyroxine ratio measurement | 1 | 1.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | retinoic acid receptor responder 3 | VGNC:10184 | 451277 | |||||
Dog | retinoic acid receptor responder 3 | VGNC:45356 | 483772 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | retinoic acid receptor responder 3 | |||||
Dog | retinoic acid receptor responder 3 | |||||
Publication Statistics
PubMed Score 82.26
PubMed score by year
PubTator Score 106.41
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (25)
Items per page:
0 of 0
PMID | Year | Title |
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