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Tbio
AGO1
Protein argonaute-1

Protein Summary
Description
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373204
  • ENSP00000362300
  • ENSG00000092847

Symbol
  • EIF2C1
  • Q99
  • EIF2C
  • hAgo1
  • EIF2C1
  • GERP95
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
pathway
0.99
hub protein
0.94
interacting protein
0.94
biological process
0.93


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 699.04   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 699.04   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
argonaute 1, RISC catalytic component
VGNC:36
456747
Macaque
argonaute 1, RISC catalytic component
712398
Mouse
MGI:2446630
236511
Rat
RGD:1304619
313594
Pig
protein argonaute-3 [Source:RefSeq peptide;Acc:NP_001181903]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
argonaute 1, RISC catalytic component
Macaque
argonaute 1, RISC catalytic component
Mouse
Rat
Pig
protein argonaute-3 [Source:RefSeq peptide;Acc:NP_001181903]
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UL18-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (37)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (34)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (286)
1 – 10 of 286
HSP90AA4P
Tdark
p_int: 0.999996792
p_ni: 0.000003203
p_wrong: 5e-9
Data Source: BioPlex
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
p_int: 0.999984227
p_ni: 0.000015773
Score: 0.383
Data Source: BioPlex,STRINGDB
DICER1
Tbio
Family: Enzyme
Novelty: 0.000306
p_int: 0.999931265
p_ni: 0.000068735
Score: 0.999
Data Source: BioPlex,STRINGDB
TARBP2
Tbio
Novelty: 0.01485994
p_int: 0.999915989
p_ni: 0.000084011
Score: 0.983
Data Source: BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int: 0.999679815
p_ni: 0.000318342
p_wrong: 0.000001844
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.999605546
p_ni: 0.000394274
p_wrong: 1.79e-7
Data Source: BioPlex
AGO3
Tbio
Novelty: 0.01664154
p_int: 0.99907898
p_ni: 0.00092102
Score: 0.974
Data Source: BioPlex,STRINGDB
TRMT13
Tdark
Novelty: 3.91234304
p_int: 0.996574534
p_ni: 0.003393883
p_wrong: 0.000031584
Data Source: BioPlex
HSP90AB1
Tchem
Novelty: 0.00907961
p_int: 0.987080454
p_ni: 0.012919546
Score: 0.353
Data Source: BioPlex,STRINGDB
RBMS1
Tbio
Novelty: 0.00520684
p_int: 0.983330347
p_ni: 0.013018736
p_wrong: 0.003650917
Score: 0.235
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  699.04

PubMed score by year
PubTator Score  139.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer