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Tbio
TBX21
T-box transcription factor TBX21

Protein Summary
Description
Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000177694
  • ENSP00000177694
  • ENSG00000073861

Symbol
  • TBET
  • TBLYM
  • TBET
  • T-PET
  • T-bet
  • TBLYM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
biological term
0.68
gene perturbation
0.65
pathway
0.64
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1044.7   (req: < 5)
Gene RIFs: 173   (req: <= 3)
Antibodies: 634   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1044.7   (req: >= 5)
Gene RIFs: 173   (req: > 3)
Antibodies: 634   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (266)
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.996
Data Source:  STRINGDB
RUNX3
Tbio
Family:  TF
Novelty:  0.00144472
Score:  0.965
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.93
Data Source:  STRINGDB
IL17A
Tclin
Novelty:  0.00011583
Score:  0.928
Data Source:  STRINGDB
CXCR3
Tchem
Family:  GPCR
Novelty:  0.00100538
Score:  0.91
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.908
Data Source:  STRINGDB
IFNG
Tclin
Novelty:  0.00009731
Score:  0.901
Data Source:  STRINGDB
ITK
Tclin
Family:  Kinase
Novelty:  0.00054195
Score:  0.901
Data Source:  STRINGDB
BCL6
Tchem
Family:  TF
Novelty:  0.00066258
Score:  0.899
Data Source:  STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.893
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (10)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Inflammatory bowel disease (IBD)
KEGG
Th17 cell differentiation
KEGG
Th1 and Th2 cell differentiation
Name
Explore in Pharos
Explore in Source
Inflammatory bowel disease (IBD)
Th17 cell differentiation
Th1 and Th2 cell differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Inferred by Curator (IC)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
3
4
89.1
total cholesterol measurement
2
3
4
87.3
serum non-albumin protein measurement
1
3
3
87.3
sex hormone-binding globulin measurement
2
1
2
85.6
pulse pressure measurement
1
1
1
80.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
89.1
total cholesterol measurement
4
87.3
serum non-albumin protein measurement
3
87.3
sex hormone-binding globulin measurement
2
85.6
pulse pressure measurement
1
80.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 21
VGNC:9678
749275
Macaque
T-box 21
694044
Mouse
MGI:1888984
57765
Rat
RGD:1308264
303496
Dog
T-box 21
VGNC:47173
491044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 21
Macaque
T-box 21
Mouse
Rat
Dog
T-box 21
Publication Statistics
PubMed Score 1044.70
PubMed score by year
PubTator Score 366.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title