Tbio BAG5 BAG family molecular chaperone regulator 5

Protein Summary

Description

Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UL15
• O94950
• Q86W59
• BAG-5

Gene Name

• BAG5

Ensembl ID

• ENST00000299204
• ENSP00000299204
• ENSG00000166170
• ENST00000337322
• ENSP00000338814
• ENST00000445922
• ENSP00000391713

Symbol

• KIAA0873
• BAG-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.78
biological process	0.74
histone modification site profile	0.66
transcription factor	0.65
transcription factor binding site profile	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.05   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 464   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.05   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0