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Tbio
BAG5
BAG family molecular chaperone regulator 5

Protein Summary
Description
Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299204
  • ENSP00000299204
  • ENSG00000166170
  • ENST00000337322
  • ENSP00000338814
  • ENST00000445922
  • ENSP00000391713

Symbol
  • KIAA0873
  • BAG-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.78
biological process
0.74
histone modification site profile
0.66
transcription factor
0.65
transcription factor binding site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.25   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.25   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
MAD1L1
Tbio
Novelty:  0.03550138
p_int:  0.999980124
p_ni:  0.000019875
Score:  0.277
Data Source:  BioPlex,STRINGDB
ABL2
Tchem
Family:  Kinase
Novelty:  0.00952983
p_int:  0.999333008
p_ni:  0.00053023
p_wrong:  0.000136763
Score:  0.538
Data Source:  BioPlex,STRINGDB
P2RX6
Tchem
Family:  IC
Novelty:  0.02091945
p_int:  0.936324998
p_ni:  0.063675002
Score:  0.29
Data Source:  BioPlex,STRINGDB
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
p_int:  0.928888732
p_ni:  0.071111268
Score:  0.183
Data Source:  BioPlex,STRINGDB
GPAT2
Tbio
Family:  Enzyme
Novelty:  0.03807198
p_int:  0.902142979
p_ni:  0.097857021
Data Source:  BioPlex
KLHL10
Tdark
Novelty:  0.09497583
p_int:  0.858493575
p_ni:  0.141506425
Data Source:  BioPlex
ABHD15
Tdark
Family:  Enzyme
Novelty:  1.53507944
p_int:  0.798463356
p_ni:  0.201536644
Score:  0.243
Data Source:  BioPlex,STRINGDB
POLR3E
Tbio
Family:  Enzyme
Novelty:  0.06500715
p_int:  0.776497322
p_ni:  0.223502678
Score:  0.183
Data Source:  BioPlex,STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.992
Data Source:  STRINGDB
HSPA1B
Tbio
Novelty:  0.01429214
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
3
4
91.4
heel bone mineral density
1
2
2
83.1
intelligence
7
9
3
6
82.3
serum gamma-glutamyl transferase measurement
1
1
1
77.3
7
4
2
1.1
77
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
91.4
heel bone mineral density
2
83.1
intelligence
3
6
82.3
serum gamma-glutamyl transferase measurement
1
77.3
2
1.1
77
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BCL2 associated athanogene 5
699170
Mouse
MGI:1917619
70369
Rat
RGD:9457021
103690404
Dog
BCL2 associated athanogene 5
VGNC:38367
480444
Horse
BCL2 associated athanogene 5
VGNC:15755
100146239
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BCL2 associated athanogene 5
Mouse
Rat
Dog
BCL2 associated athanogene 5
Horse
BCL2 associated athanogene 5
Publication Statistics
PubMed Score 38.25
PubMed score by year
PubTator Score 13.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title