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Tbio
BAG5
BAG family molecular chaperone regulator 5

Protein Summary
Description
Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299204
  • ENSP00000299204
  • ENSG00000166170
  • ENST00000337322
  • ENSP00000338814
  • ENST00000445922
  • ENSP00000391713

Symbol
  • KIAA0873
  • BAG-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.78
biological process
0.74
histone modification site profile
0.66
transcription factor
0.65
transcription factor binding site profile
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.68   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.68   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BCL2 associated athanogene 5
699170
Mouse
MGI:1917619
70369
Rat
RGD:9457021
103690404
Dog
BCL2 associated athanogene 5
VGNC:38367
480444
Horse
BCL2 associated athanogene 5
VGNC:15755
100146239
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BCL2 associated athanogene 5
Mouse
Rat
Dog
BCL2 associated athanogene 5
Horse
BCL2 associated athanogene 5
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UL15-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Protein-Protein Interactions (54)
1 – 10 of 54
MAD1L1
Tbio
Novelty: 0.03550138
p_int: 0.999980124
p_ni: 0.000019875
Score: 0.277
Data Source: BioPlex,STRINGDB
ABL2
Tchem
Family: Kinase
Novelty: 0.00952983
p_int: 0.999333008
p_ni: 0.00053023
p_wrong: 0.000136763
Score: 0.538
Data Source: BioPlex,STRINGDB
P2RX6
Tchem
Family: IC
Novelty: 0.02091945
p_int: 0.936324998
p_ni: 0.063675002
Score: 0.29
Data Source: BioPlex,STRINGDB
KCNC4
Tclin
Family: IC
Novelty: 0.01215128
p_int: 0.928888732
p_ni: 0.071111268
Score: 0.183
Data Source: BioPlex,STRINGDB
GPAT2
Tbio
Family: Enzyme
Novelty: 0.03807198
p_int: 0.902142979
p_ni: 0.097857021
Data Source: BioPlex
KLHL10
Tdark
Novelty: 0.09497583
p_int: 0.858493575
p_ni: 0.141506425
Data Source: BioPlex
ABHD15
Tdark
Family: Enzyme
Novelty: 1.53507944
p_int: 0.798463356
p_ni: 0.201536644
Score: 0.243
Data Source: BioPlex,STRINGDB
POLR3E
Tbio
Family: Enzyme
Novelty: 0.06500715
p_int: 0.776497322
p_ni: 0.223502678
Score: 0.183
Data Source: BioPlex,STRINGDB
HSPA1A
Tchem
Novelty: 0.00069195
Score: 0.992
Data Source: STRINGDB
HSPA1B
Tbio
Novelty: 0.01429214
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.68

PubMed score by year
PubTator Score  13.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer