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Tbio
CNOT11
CCR4-NOT transcription complex subunit 11

Protein Summary
Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289382
  • ENSP00000289382
  • ENSG00000158435

Symbol
  • C2orf29
  • C40
  • C2orf29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
interacting protein
0.86
cell type or tissue
0.85
protein complex
0.83
histone modification site profile
0.7


Related Tools
GENEVA
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 11
VGNC:207
743599
Macaque
CCR4-NOT transcription complex subunit 11
710844
Mouse
MGI:106580
52846
Rat
RGD:1560909
363221
Dog
CCR4-NOT transcription complex subunit 11
VGNC:39412
481334
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 11
Macaque
CCR4-NOT transcription complex subunit 11
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKZ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (69)
1 – 10 of 69
CNOT7
Tchem
Novelty: 0.04551853
p_int: 0.999999996
p_ni: 4e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
CNOT6
Tbio
Novelty: 0.03605299
p_int: 0.99999991
p_ni: 8.9e-8
p_wrong: 1e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
CNOT6L
Tbio
Novelty: 0.06038336
p_int: 0.999999759
p_ni: 2.4e-7
Score: 0.993
Data Source: BioPlex,STRINGDB
CNOT2
Tbio
Novelty: 0.01886737
p_int: 0.999999129
p_ni: 8.71e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
NANOS2
Tbio
Novelty: 0.01489157
p_int: 0.999996879
p_ni: 0.000003121
Score: 0.873
Data Source: BioPlex,STRINGDB
TNKS1BP1
Tbio
Family: Enzyme
Novelty: 0.21682007
p_int: 0.999996445
p_ni: 0.000003555
Score: 0.99
Data Source: BioPlex,STRINGDB
CNOT3
Tbio
Novelty: 0.02463568
p_int: 0.999993631
p_ni: 0.00000637
Score: 0.995
Data Source: BioPlex,STRINGDB
CNOT10
Tdark
Novelty: 0.30195594
p_int: 0.999988947
p_ni: 0.00001105
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RIBC1
Tdark
Novelty: 0.40435429
p_int: 0.999987442
p_ni: 0.000012558
Score: 0.826
Data Source: BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty: 9.51798561
p_int: 0.999981738
p_ni: 0.000018002
p_wrong: 2.61e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  50.83

PubMed score by year
PubTator Score  123.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer