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Tbio
ZHX1
Zinc fingers and homeoboxes protein 1

Protein Classes
Protein Summary
Description
Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297857
  • ENSP00000297857
  • ENSG00000165156
  • ENST00000395571
  • ENSP00000378938
  • ENST00000522655
  • ENSP00000428821
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
PubMedID
0.72
hub protein
0.71
kinase perturbation
0.71
tissue sample
0.65


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.74   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.74   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc fingers and homeoboxes 1
VGNC:762
464368
Macaque
zinc fingers and homeoboxes 1
704254
Mouse
MGI:109271
22770
Rat
RGD:620010
171159
Dog
zinc fingers and homeoboxes 1
VGNC:48631
475089
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc fingers and homeoboxes 1
Macaque
zinc fingers and homeoboxes 1
Mouse
Rat
Dog
zinc fingers and homeoboxes 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UKY1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (27)
1 – 10 of 27
WDR83
Tbio
Novelty:  0.11602568
p_int:  1
Score:  0.173
Data Source:  BioPlex,STRINGDB
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.954983887
p_ni:  0.004365882
p_wrong:  0.040650231
Data Source:  BioPlex
LHX9
Tbio
Family:  TF
Novelty:  0.02952374
p_int:  0.790003008
p_ni:  0.000514307
p_wrong:  0.209482685
Score:  0.544
Data Source:  BioPlex,STRINGDB
NFYA
Tbio
Family:  TF
Novelty:  0.00507094
Score:  0.874
Data Source:  STRINGDB
BPGM
Tbio
Family:  Enzyme
Novelty:  0.03437401
Score:  0.8
Data Source:  STRINGDB
ZMYND11
Tbio
Family:  Epigenetic
Novelty:  0.02485283
Score:  0.758
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.693
Data Source:  STRINGDB
NFYC
Tbio
Family:  TF
Novelty:  0.00626931
Score:  0.684
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.662
Data Source:  STRINGDB
VWA5A
Tbio
Novelty:  0.0802354
Score:  0.641
Data Source:  STRINGDB
Publication Statistics
PubMed Score  24.74

PubMed score by year
PubTator Score  12.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer