You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ITGA11
Integrin alpha-11

Protein Summary
Description
Integrin alpha-11/beta-1 is a receptor for collagen. This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315757
  • ENSP00000327290
  • ENSG00000137809
  • ENST00000423218
  • ENSP00000403392

Symbol
  • HsT18964
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.71
tissue
0.68
molecular function
0.63
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.31   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.31   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (52)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Integrin cell surface interactions
Protein-Protein Interactions (103)
1 – 10 of 103
ITGB1
Tclin
Novelty: 0.00074903
Score: 0.978
Data Source: Reactome,STRINGDB
ITGB8
Tbio
Novelty: 0.02328147
Score: 0.97
Data Source: STRINGDB
ITGB5
Tbio
Novelty: 0.02400591
Score: 0.966
Data Source: STRINGDB
ITGB7
Tclin
Novelty: 0.02027194
Score: 0.962
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00086996
Score: 0.961
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00237551
Score: 0.956
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00095231
Score: 0.945
Data Source: STRINGDB
ITGB6
Tbio
Novelty: 0.01484532
Score: 0.936
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00057274
Score: 0.933
Data Source: STRINGDB
ITGA8
Tbio
Novelty: 0.03628382
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.31

PubMed score by year
PubTator Score  15.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: