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Tbio
ITGA11
Integrin alpha-11

Protein Summary
Description
Integrin alpha-11/beta-1 is a receptor for collagen. This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315757
  • ENSP00000327290
  • ENSG00000137809
  • ENST00000423218
  • ENSP00000403392

Symbol
  • HsT18964
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.71
tissue
0.68
molecular function
0.63
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.48   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.48   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
1
1
0
1.3
47.2
systolic blood pressure
1
1
1
27.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
0
1.3
47.2
systolic blood pressure
1
27.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 11
VGNC:3542
453537
Mouse
MGI:2442114
319480
Rat
RGD:1311711
315744
Dog
integrin subunit alpha 11
VGNC:42122
478353
Horse
integrin subunit alpha 11
VGNC:19162
100065211
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 11
Mouse
Rat
Dog
integrin subunit alpha 11
Horse
integrin subunit alpha 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKX5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (52)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Integrin cell surface interactions
Protein-Protein Interactions (103)
1 – 10 of 103
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.978
Data Source: Reactome,STRINGDB
ITGB8
Tbio
Novelty: 0.01564348
Score: 0.97
Data Source: STRINGDB
ITGB5
Tbio
Novelty: 0.01455909
Score: 0.966
Data Source: STRINGDB
ITGB7
Tclin
Novelty: 0.01290005
Score: 0.962
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.961
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.956
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.945
Data Source: STRINGDB
ITGB6
Tbio
Novelty: 0.01118242
Score: 0.936
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.933
Data Source: STRINGDB
ITGA8
Tbio
Novelty: 0.0220023
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.48

PubMed score by year
PubTator Score  15.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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