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Tbio
MYH2
Myosin-2

Protein Summary
Description
Muscle contraction. Required for cytoskeleton organization (By similarity). Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245503
  • ENSP00000245503
  • ENSG00000125414
  • ENST00000397183
  • ENSP00000380367
  • ENST00000532183
  • ENSP00000433944
  • ENST00000622564
  • ENSP00000482463

Symbol
  • MYHSA2
  • IBM3
  • MYH2A
  • MYPOP
  • MYHSA2
  • MYHas8
  • MyHC-2A
  • MyHC-IIa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
gene perturbation
0.95
co-expressed gene
0.89
protein domain
0.85
cellular component
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.1   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.1   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 2
VGNC:12477
455073
Macaque
myosin, heavy chain 2, skeletal muscle, adult
717912
Mouse
MGI:1339710
17882
Horse
myosin heavy chain 2
VGNC:49493
791236
Cow
myosin heavy chain 2
VGNC:54459
788772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 2
Macaque
myosin, heavy chain 2, skeletal muscle, adult
Mouse
Horse
myosin heavy chain 2
Cow
myosin heavy chain 2
Pathways (10)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of actin dynamics for phagocytic cup formation
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Regulation of actin dynamics for phagocytic cup formation
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (142)
1 – 10 of 142
TLE3
Tbio
Novelty: 0.02641884
p_int: 1
Score: 0.219
Data Source: BioPlex,STRINGDB
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.999999999
p_ni: 1e-9
Data Source: BioPlex
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999999999
p_ni: 1e-9
p_wrong: 1e-9
Data Source: BioPlex
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 1e-9
Data Source: BioPlex
HIF1A
Tchem
Family: TF
Novelty: 0.00011503
p_int: 0.999999992
p_ni: 7e-9
p_wrong: 1e-9
Score: 0.307
Data Source: BioPlex,STRINGDB
MYL1
Tbio
Novelty: 0.00360262
Score: 0.967
Data Source: STRINGDB
MYH1
Tbio
Novelty: 0.00472973
Score: 0.958
Data Source: STRINGDB
MYLPF
Tbio
Novelty: 0.00960325
Score: 0.956
Data Source: STRINGDB
MYL3
Tbio
Novelty: 0.00493817
Score: 0.947
Data Source: STRINGDB
MYL6B
Tbio
Novelty: 0.01292785
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  236.10

PubMed score by year
PubTator Score  81.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer