MYH2
Myosin-2
Protein Summary
Muscle contraction. Required for cytoskeleton organization (By similarity). Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
- ENST00000245503
- ENSP00000245503
- ENSG00000125414
- ENST00000397183
- ENSP00000380367
- ENST00000532183
- ENSP00000433944
- ENST00000622564
- ENSP00000482463
- MYHSA2
- IBM3
- MYH2A
- MYPOP
- MYHSA2
- MYHas8
- MyHC-2A
- MyHC-IIa
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
gene perturbation | 0.95 | ||
co-expressed gene | 0.89 | ||
protein domain | 0.85 | ||
cellular component | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 272.11 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 111 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 272.11 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 111 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0