Protein Summary
Muscle contraction. Required for cytoskeleton organization (By similarity). Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
- ENST00000245503
- ENSP00000245503
- ENSG00000125414
- ENST00000397183
- ENSP00000380367
- ENST00000532183
- ENSP00000433944
- ENST00000622564
- ENSP00000482463
- MYHSA2
- IBM3
- MYH2A
- MYPOP
- MYHSA2
- MYHas8
- MyHC-2A
- MyHC-IIa
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
gene perturbation | 0.95 | ||
co-expressed gene | 0.89 | ||
protein domain | 0.85 | ||
cellular component | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.99 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 111 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.99 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 111 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (142)
MECOM
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999999999
p_ni: 1e-9
p_wrong: 1e-9
Data Source: BioPlex
HIF1A
Family: TF
Novelty: 0.00011503
p_int: 0.999999992
p_ni: 7e-9
p_wrong: 1e-9
Score: 0.307
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (4)
KEGG (1)
PathwayCommons (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Regulation of actin dynamics for phagocytic cup formation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Immune System | ||||
Innate Immune System | ||||
Regulation of actin dynamics for phagocytic cup formation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myosin heavy chain 2 | VGNC:12477 | 455073 | |||||
Macaque | myosin, heavy chain 2, skeletal muscle, adult | 717912 | ||||||
Mouse | MGI:1339710 | 17882 | ||||||
Horse | myosin heavy chain 2 | VGNC:49493 | 791236 | |||||
Cow | myosin heavy chain 2 | VGNC:54459 | 788772 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myosin heavy chain 2 | |||||
Macaque | myosin, heavy chain 2, skeletal muscle, adult | |||||
Mouse | ||||||
Horse | myosin heavy chain 2 | |||||
Cow | myosin heavy chain 2 | |||||
Publication Statistics
PubMed Score 243.99
PubMed score by year
PubTator Score 81.33
PubTator score by year
Related Publications
Text Mined References (44)
GeneRif Annotations (23)
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