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Tbio
ELF5
ETS-related transcription factor Elf-5

Protein Summary
Description
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257832
  • ENSP00000257832
  • ENSG00000135374
  • ENST00000312319
  • ENSP00000311010
  • ENST00000429939
  • ENSP00000407589
  • ENST00000532417
  • ENSP00000436386

Symbol
  • ESE2
  • ESE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.63
cell line
0.61
molecular function
0.6
biological process
0.59
protein domain
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.59   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.59   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
WFDC5
Tbio
Novelty:  0.0457192
Score:  0.802
Data Source:  STRINGDB
PDZD4
Tbio
Novelty:  0.00603543
Score:  0.801
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.696
Data Source:  STRINGDB
CDX2
Tbio
Family:  TF
Novelty:  0.00081636
Score:  0.678
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.658
Data Source:  STRINGDB
KRT18
Tbio
Novelty:  0.00069055
Score:  0.643
Data Source:  STRINGDB
EOMES
Tbio
Family:  TF
Novelty:  0.00288125
Score:  0.633
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.626
Data Source:  STRINGDB
TEAD4
Tchem
Family:  TF
Novelty:  0.0114979
Score:  0.624
Data Source:  STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.54
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
1
1
1
37.6
serum gamma-glutamyl transferase measurement
1
1
1
7.1
glycoprotein measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
1
37.6
serum gamma-glutamyl transferase measurement
1
7.1
glycoprotein measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E74 like ETS transcription factor 5
VGNC:8192
739906
Macaque
E74 like ETS transcription factor 5
717377
Mouse
MGI:1335079
13711
Rat
RGD:1305859
366142
Dog
E74 like ETS transcription factor 5
VGNC:40302
608908
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E74 like ETS transcription factor 5
Macaque
E74 like ETS transcription factor 5
Mouse
Rat
Dog
E74 like ETS transcription factor 5
Publication Statistics
PubMed Score 78.59
PubMed score by year
PubTator Score 41.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title