You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
VAV3
Guanine nucleotide exchange factor VAV3

Protein Summary
Description
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370056
  • ENSP00000359073
  • ENSG00000134215
  • ENST00000415432
  • ENSP00000394897
  • ENST00000527011
  • ENSP00000432540
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.99
biological process
0.94
hub protein
0.92
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.83   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.83   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (95)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
DAP12 interactions
DAP12 signaling
Death Receptor Signalling
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (166)
1 – 10 of 166
SYK
Tclin
Family: Kinase
Novelty: 0.00067612
Score: 0.986
Data Source: Reactome,STRINGDB
LCP2
Tbio
Novelty: 0.00631737
Score: 0.986
Data Source: Reactome,STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00123743
Score: 0.985
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.05044614
Score: 0.983
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00579565
Score: 0.981
Data Source: Reactome,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00039759
Score: 0.978
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.0002729
Score: 0.978
Data Source: Reactome,STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.0076798
Score: 0.978
Data Source: Reactome,STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.00359609
Score: 0.962
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00407673
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  81.83

PubMed score by year
PubTator Score  65.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: