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Tbio
AMFR
E3 ubiquitin-protein ligase AMFR

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290649
  • ENSP00000290649
  • ENSG00000159461

Symbol
  • RNF45
  • GP78
  • RNF45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
kinase perturbation
0.95
PubMedID
0.92
cellular component
0.84
cell type or tissue
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.6   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.6   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
p_int:  0.961724534
p_ni:  0.038275466
Data Source:  BioPlex
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.928835521
p_ni:  0.071164479
Score:  0.587
Data Source:  BioPlex,STRINGDB
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.920276757
p_ni:  0.079723243
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.905533507
p_ni:  0.094466493
Score:  0.45
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.884418656
p_ni:  0.115581344
Data Source:  BioPlex
HSD17B3
Tchem
Family:  Enzyme
Novelty:  0.00666322
p_int:  0.883467312
p_ni:  0.116532688
Score:  0.226
Data Source:  BioPlex,STRINGDB
HTR3E
Tchem
Family:  IC
Novelty:  0.06082317
p_int:  0.850492146
p_ni:  0.149507854
Score:  0.455
Data Source:  BioPlex,STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
p_int:  0.80769717
p_ni:  0.19230283
Data Source:  BioPlex
SLC13A2
Tbio
Family:  Transporter
Novelty:  0.01020451
p_int:  0.805641851
p_ni:  0.194358149
Score:  0.552
Data Source:  BioPlex,STRINGDB
GLRA2
Tchem
Family:  IC
Novelty:  0.02839305
p_int:  0.782056818
p_ni:  0.217943182
Score:  0.21
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
ER Quality Control Compartment (ERQC)
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
1
1
88.7
high density lipoprotein cholesterol measurement
2
3
3
75.7
depressive symptom measurement
2
2
2
60.1
neuroticism measurement
2
2
2
60.1
apolipoprotein A 1 measurement
1
2
2
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
88.7
high density lipoprotein cholesterol measurement
3
75.7
depressive symptom measurement
2
60.1
neuroticism measurement
2
60.1
apolipoprotein A 1 measurement
2
55.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autocrine motility factor receptor
VGNC:9019
735643
Macaque
autocrine motility factor receptor
699972
Mouse
MGI:1345634
23802
Rat
RGD:1311551
361367
Dog
autocrine motility factor receptor
VGNC:37829
487269
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autocrine motility factor receptor
Macaque
autocrine motility factor receptor
Mouse
Rat
Dog
autocrine motility factor receptor
Publication Statistics
PubMed Score 205.60
PubMed score by year
PubTator Score 124.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title