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Tbio
ACIN1
Apoptotic chromatin condensation inducer in the nucleus

Protein Summary
Description
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different fr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262710
  • ENSP00000262710
  • ENSG00000100813
  • ENST00000338631
  • ENSP00000345541
  • ENST00000357481
  • ENSP00000350073
  • ENST00000397341
  • ENSP00000380502
  • ENST00000555053
  • ENSP00000451328

Symbol
  • ACINUS
  • KIAA0670
  • ACN
  • ACINUS
  • fSAP152
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
interacting protein
0.94
disease perturbation
0.93
transcription factor binding site profile
0.87
ligand (protein) perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.75   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 495   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.75   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.999995323
p_ni:  0.000004677
Score:  0.412
Data Source:  BioPlex,STRINGDB
LUC7L2
Tbio
Novelty:  0.36989457
p_int:  0.999991411
p_ni:  0.000008589
Data Source:  BioPlex
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999991267
p_ni:  0.000008733
Data Source:  BioPlex
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.999988899
p_ni:  0.000011101
Data Source:  BioPlex
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.999987858
p_ni:  0.000012141
Score:  0.998
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.999984628
p_ni:  0.000015372
Data Source:  BioPlex
EPB41L2
Tbio
Novelty:  0.0311733
p_int:  0.999973553
p_ni:  0.000026447
Score:  0.158
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999952588
p_ni:  0.000047412
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999940158
p_ni:  0.000059842
Data Source:  BioPlex
WSB2
Tbio
Novelty:  0.03939755
p_int:  0.999864976
p_ni:  0.000135024
Score:  0.461
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Programmed Cell Death
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
6
10
97.3
basophil count
7
7
11
95
basophil percentage of leukocytes
2
5
5
94
2
2
0
1.3
92.6
monocyte count
7
2
7
90.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
97.3
basophil count
11
95
basophil percentage of leukocytes
5
94
0
1.3
92.6
monocyte count
7
90.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apoptotic chromatin condensation inducer 1
VGNC:3510
452792
Macaque
apoptotic chromatin condensation inducer 1
713310
Mouse
MGI:1891824
56215
Rat
RGD:1311945
305884
Dog
apoptotic chromatin condensation inducer 1
VGNC:37507
480247
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apoptotic chromatin condensation inducer 1
Macaque
apoptotic chromatin condensation inducer 1
Mouse
Rat
Dog
apoptotic chromatin condensation inducer 1
Publication Statistics
PubMed Score 55.75
PubMed score by year
PubTator Score 32.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title