Tbio ACIN1 Apoptotic chromatin condensation inducer in the nucleus

Protein Summary

Description

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9UKV3
• B2RTT4
• D3DS45
• O75158
• Q9UG91
• Q9UKV1
• Q9UKV2
• Acinus

Gene Name

• ACIN1

Ensembl ID

• ENST00000262710
• ENSP00000262710
• ENSG00000100813
• ENST00000338631
• ENSP00000345541
• ENST00000357481
• ENSP00000350073
• ENST00000397341
• ENSP00000380502
• ENST00000555053
• ENSP00000451328

Symbol

• ACINUS
• KIAA0670
• ACN
• ACINUS
• fSAP152

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
interacting protein	0.94
disease perturbation	0.93
transcription factor binding site profile	0.87
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.94   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 495   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.94   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (110)

Explore Interacting Targets

1 – 10 of 110

• See Interactions on String-DB

SNIP1

Tbio

Novelty:  0.01865867

p_int:  0.999995323

p_ni:  0.000004677

Score:  0.412

Data Source:  BioPlex,STRINGDB

LUC7L2

Tdark

Novelty:  0.36989457

p_int:  0.999991411

p_ni:  0.000008589

Data Source:  BioPlex

CAMKV

Tbio

Family:  Kinase

Novelty:  0.17794181

p_int:  0.999991267

p_ni:  0.000008733

Data Source:  BioPlex

EPB41L1

Tbio

Novelty:  0.02937451

p_int:  0.999988899

p_ni:  0.000011101

Data Source:  BioPlex

SAP18

Tbio

Family:  Enzyme

Novelty:  0.03918373

p_int:  0.999987858

p_ni:  0.000012141

Score:  0.998

Data Source:  BioPlex,STRINGDB

NKAPD1

Tdark

Novelty:  1.56979675

p_int:  0.999984628

p_ni:  0.000015372

Data Source:  BioPlex

EPB41L2

Tbio

Novelty:  0.0311733

p_int:  0.999973553

p_ni:  0.000026447

Score:  0.158

Data Source:  BioPlex,STRINGDB

EPB41L3

Tbio

Novelty:  0.00915217

p_int:  0.999952588

p_ni:  0.000047412

Data Source:  BioPlex

PIP4K2A

Tbio

Family:  Kinase

Novelty:  0.01130885

p_int:  0.999940158

p_ni:  0.000059842

Data Source:  BioPlex

WSB2

Tbio

Novelty:  0.03939755

p_int:  0.999864976

p_ni:  0.000135024

Score:  0.461

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (4)

KEGG (3)

Apoptosis (R-HSA-109581)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Reactome	Apoptotic execution phase	52 targets	R-HSA-75153
Reactome	Programmed Cell Death	180 targets	R-HSA-5357801

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Apoptotic execution phase	52 targets	R-HSA-75153
Programmed Cell Death	180 targets	R-HSA-5357801

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (4)

Components (7)

Processes (7)

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1 – 4 of 4

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATPase activity	Non-traceable Author Statement (NAS)	UniProtKB
enzyme binding	Non-traceable Author Statement (NAS)	UniProtKB
nucleic acid binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (24)

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5

1 – 5 of 24

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	6	6	10		99.4
eosinophil count	EFO_0004842	3	5	7		98
basophil count	EFO_0005090	5	7	9		98
eosinophil percentage of leukocytes	EFO_0007991	2	7	9		97
reticulocyte count	EFO_0007986	6	3	6		97

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 24

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	10		99.4
eosinophil count	EFO_0004842	7		98
basophil count	EFO_0005090	9		98
eosinophil percentage of leukocytes	EFO_0007991	9		97
reticulocyte count	EFO_0007986	6		97

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Apoptosis
Complete proteome
Direct protein sequencing
Isopeptide bond
Methylation
mRNA processing
mRNA splicing

GWAS Trait Find Similar Targets

No Header	No Header
acute lymphoblastic leukemia
B-cell acute lymphoblastic leukemia
basophil count
basophil percentage of granulocytes
basophil percentage of leukocytes
cognitive function measurement
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
FEV/FEC ratio

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	apoptotic chromatin condensation inducer 1	VGNC:3510	452792
Macaque	apoptotic chromatin condensation inducer 1		713310
Mouse	apoptotic chromatin condensation inducer 1	MGI:1891824	56215
Rat	apoptotic chromatin condensation inducer 1	RGD:1311945	305884
Dog	apoptotic chromatin condensation inducer 1	VGNC:37507	480247

Species	Name	OMA	EggNOG	Inparanoid
Chimp	apoptotic chromatin condensation inducer 1
Macaque	apoptotic chromatin condensation inducer 1
Mouse	apoptotic chromatin condensation inducer 1
Rat	apoptotic chromatin condensation inducer 1
Dog	apoptotic chromatin condensation inducer 1

Publication Statistics

PubMed Score 48.94

PubMed score by year

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PubTator Score 32.42

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Related Publications

Text Mined References (37)

GeneRif Annotations (17)

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PMID	Year	Title