Tclin HDAC9 Histone deacetylase 9

Protein Summary

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UKV0
• A7E2F3
• B7Z4I4
• B7Z917
• B7Z928
• B7Z940
• C9JS87
• E7EX34
• F8W9E0
• O94845
• O95028
• Q2M2R6
• Q86SL1
• Q86US3
• HD9

Gene Name

• HDAC9

Ensembl ID

• ENST00000401921
• ENSP00000383912
• ENSG00000048052
• ENST00000405010
• ENSP00000384382
• ENST00000406451
• ENSP00000384657
• ENST00000417496
• ENSP00000401669
• ENST00000428307
• ENSP00000395655
• ENST00000432645
• ENSP00000410337
• ENST00000441542
• ENSP00000408617
• ENST00000456174
• ENSP00000388568
• ENST00000524023
• ENSP00000430036

Symbol

• HDAC7
• HDAC7B
• HDRP
• KIAA0744
• MITR
• HD7
• HD9
• HD7b
• HDAC
• HDRP
• MITR
• HDAC7
• HDAC7B
• HDAC9B
• HDAC9FL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
virus perturbation	0.99
biological process	0.96
molecular function	0.96
hub protein	0.92

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class Iia / Histone Deacetylase 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.43   (req: < 5)

Gene RIFs: 109   (req: <= 3)

Antibodies: 532   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.43   (req: >= 5)

Gene RIFs: 109   (req: > 3)

Antibodies: 532   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 123

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4