You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
HDAC9
Histone deacetylase 9

Protein Summary
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401921
  • ENSP00000383912
  • ENSG00000048052
  • ENST00000405010
  • ENSP00000384382
  • ENST00000406451
  • ENSP00000384657
  • ENST00000417496
  • ENSP00000401669
  • ENST00000428307
  • ENSP00000395655
  • ENST00000432645
  • ENSP00000410337
  • ENST00000441542
  • ENSP00000408617
  • ENST00000456174
  • ENSP00000388568
  • ENST00000524023
  • ENSP00000430036

Symbol
  • HDAC7
  • HDAC7B
  • HDRP
  • KIAA0744
  • MITR
  • HD7
  • HD9
  • HD7b
  • HDAC
  • HDRP
  • MITR
  • HDAC7
  • HDAC7B
  • HDAC9B
  • HDAC9FL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
virus perturbation
0.99
biological process
0.96
molecular function
0.96
hub protein
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.31   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 532   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.31   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 532   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 101
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (101)
fimepinostat
Rendered image for fimepinostat
trichostatin
Rendered image for trichostatin
CUDC-101
Rendered image for CUDC-101
Belinosta
Rendered image for Belinosta
CHEMBL1830424
Rendered image for CHEMBL1830424
dacinostat
Rendered image for dacinostat
KA1010
Rendered image for KA1010
pracinostat
Rendered image for pracinostat
quisinostat
Rendered image for quisinostat
scriptaid
Rendered image for scriptaid
Protein-Protein Interactions (212)
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.979
Data Source:  STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.974
Data Source:  STRINGDB
MEF2A
Tbio
Family:  TF
Novelty:  0.00439393
Score:  0.973
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.972
Data Source:  STRINGDB
MEF2D
Tbio
Family:  TF
Novelty:  0.00732653
Score:  0.97
Data Source:  STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
Score:  0.968
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.966
Data Source:  STRINGDB
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.966
Data Source:  STRINGDB
NCOR2
Tchem
Family:  TF
Novelty:  0.00066449
Score:  0.966
Data Source:  STRINGDB
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Diseases of signal transduction
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
8
8
99.6
1
11
11
99
3
3
1
1.3
96.7
body height
1
4
4
92.4
platelet crit
2
2
2
92
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
8
99.6
11
99
1
1.3
96.7
body height
4
92.4
platelet crit
2
92
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 9
VGNC:4384
463280
Macaque
histone deacetylase 9
708314
Mouse
MGI:1931221
79221
Rat
RGD:1310748
687001
Dog
histone deacetylase 9
VGNC:50632
482339
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone deacetylase 9
Macaque
histone deacetylase 9
Mouse
Rat
Dog
histone deacetylase 9
Publication Statistics
PubMed Score 289.31
PubMed score by year
PubTator Score 745.98
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title