Protein Summary
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members ...more
- ENST00000401921
- ENSP00000383912
- ENSG00000048052
- ENST00000405010
- ENSP00000384382
- ENST00000406451
- ENSP00000384657
- ENST00000417496
- ENSP00000401669
- ENST00000428307
- ENSP00000395655
- ENST00000432645
- ENSP00000410337
- ENST00000441542
- ENSP00000408617
- ENST00000456174
- ENSP00000388568
- ENST00000524023
- ENSP00000430036
- HDAC7
- HDAC7B
- HDRP
- KIAA0744
- MITR
- HD7
- HD9
- HD7b
- HDAC
- HDRP
- MITR
- HDAC7
- HDAC7B
- HDAC9B
- HDAC9FL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
virus perturbation | 0.99 | ||
biological process | 0.96 | ||
molecular function | 0.96 | ||
hub protein | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 289.31 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 532 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 289.31 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 532 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 101
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (101)
Protein-Protein Interactions (212)
Nearest Tclin Targets
Pathways (27)
Reactome (15)
KEGG (2)
PathwayCommons (3)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Disease | ||||
Diseases of signal transduction | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (9)
Components (6)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations (null)
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
balding measurement | 2 | 8 | 8 | 99.6 | |||||
1 | 11 | 11 | 99 | ||||||
3 | 3 | 1 | 1.3 | 96.7 | |||||
body height | 1 | 4 | 4 | 92.4 | |||||
platelet crit | 2 | 2 | 2 | 92 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
balding measurement | 8 | 99.6 | |||||
11 | 99 | ||||||
1 | 1.3 | 96.7 | |||||
body height | 4 | 92.4 | |||||
platelet crit | 2 | 92 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histone deacetylase 9 | VGNC:4384 | 463280 | |||||
Macaque | histone deacetylase 9 | 708314 | ||||||
Mouse | MGI:1931221 | 79221 | ||||||
Rat | RGD:1310748 | 687001 | ||||||
Dog | histone deacetylase 9 | VGNC:50632 | 482339 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histone deacetylase 9 | |||||
Macaque | histone deacetylase 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histone deacetylase 9 | |||||
Publication Statistics
PubMed Score 289.31
PubMed score by year
PubTator Score 745.98
PubTator score by year
Related Publications
Text Mined References (111)
GeneRif Annotations (70)
Items per page:
0 of 0
PMID | Year | Title |
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