Tbio ANGPTL2 Angiopoietin-related protein 2

Protein Summary

Description

Induces sprouting in endothelial cells through an autocrine and paracrine action. Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UKU9
• Q5JT58
• Q8NCH7

Gene Name

• ANGPTL2

Ensembl ID

• ENST00000373417
• ENSP00000362516
• ENSG00000136859
• ENST00000373425
• ENSP00000362524

Symbol

• ARP2
• ARP2
• HARP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
disease perturbation	0.87
transcription factor perturbation	0.8
small molecule perturbation	0.76
cell type or tissue	0.73

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Angiopoietin-related Protein 2

DTO Classes

Protein / Signaling / Angiopoietin-related Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.62   (req: < 5)

Gene RIFs: 74   (req: <= 3)

Antibodies: 272   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.62   (req: >= 5)

Gene RIFs: 74   (req: > 3)

Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0