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Tbio
ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

Protein Summary
Description
Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex. This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281182
  • ENSP00000281182
  • ENSG00000151498
  • ENST00000374752
  • ENSP00000363884

Symbol
  • ARC42
  • IBD
  • ARC42
  • ACAD-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
virus perturbation
0.88
disease perturbation
0.83
protein domain
0.73
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
VPS37D
Tdark
Novelty:  1.44882563
p_int:  0.999893956
p_ni:  0.000106044
Score:  0.26
Data Source:  BioPlex,STRINGDB
VSTM2A
Tbio
Novelty:  0.34891628
p_int:  0.996051445
p_ni:  0.003948555
Score:  0.517
Data Source:  BioPlex,STRINGDB
SRGAP3
Tbio
Family:  Enzyme
Novelty:  0.01913784
p_int:  0.899120832
p_ni:  0.100879168
Score:  0.243
Data Source:  BioPlex,STRINGDB
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.866787099
p_ni:  0.133212901
Data Source:  BioPlex
FAM161B
Tdark
Novelty:  0.75966762
p_int:  0.849226158
p_ni:  0.150773842
Score:  0.403
Data Source:  BioPlex,STRINGDB
FCGR1A
Tclin
Novelty:  0.00073204
p_int:  0.819087734
p_ni:  0.180912266
Score:  0.189
Data Source:  BioPlex,STRINGDB
POLM
Tbio
Family:  Enzyme
Novelty:  0.00362931
p_int:  0.807032676
p_ni:  0.192967323
Score:  0.403
Data Source:  BioPlex,STRINGDB
ECHS1
Tbio
Family:  Enzyme
Novelty:  0.01291476
Score:  0.936
Data Source:  STRINGDB
BCKDHB
Tbio
Family:  Enzyme
Novelty:  0.02234969
Score:  0.935
Data Source:  STRINGDB
HADHA
Tbio
Novelty:  0.00385746
Score:  0.931
Data Source:  STRINGDB
Pathways (6)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carnitine measurement
1
1
0
9.2
76.1
brain measurement
1
1
0
7.3
47.2
blood protein measurement
1
1
1
46.3
educational attainment
1
1
1
39.7
cortical surface area measurement
1
1
0
5.8
19
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carnitine measurement
0
9.2
76.1
brain measurement
0
7.3
47.2
blood protein measurement
1
46.3
educational attainment
1
39.7
cortical surface area measurement
0
5.8
19
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase family member 8
VGNC:11254
451683
Macaque
acyl-CoA dehydrogenase family member 8
677723
Mouse
MGI:1914198
66948
Rat
RGD:1564209
367196
Dog
acyl-CoA dehydrogenase family member 8
VGNC:37492
479386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase family member 8
Macaque
acyl-CoA dehydrogenase family member 8
Mouse
Rat
Dog
acyl-CoA dehydrogenase family member 8
Publication Statistics
PubMed Score 20.21
PubMed score by year
PubTator Score 9.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title