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Tbio
TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme

Protein Summary
Description
Specific inactivation of TRH after its release. This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261180
  • ENSP00000261180
  • ENSG00000072657

Symbol
  • PAP-II
  • PGPEP2
  • TRH-DE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
microRNA
0.87
gene perturbation
0.84
histone modification site profile
0.75
disease
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.24   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.24   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
MUL1
Tbio
Family:  Enzyme
Novelty:  0.00841786
p_int:  0.99917077
p_ni:  0.00082923
Score:  0.185
Data Source:  BioPlex,STRINGDB
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.987281589
p_ni:  0.012707846
p_wrong:  0.000010566
Data Source:  BioPlex
DNAJB9
Tbio
Novelty:  0.00536296
p_int:  0.984015115
p_ni:  0.015984874
p_wrong:  1e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.983911041
p_ni:  0.016088959
Score:  0.16
Data Source:  BioPlex,STRINGDB
EMILIN2
Tbio
Novelty:  0.2816786
p_int:  0.946201136
p_ni:  0.018746299
p_wrong:  0.035052566
Score:  0.189
Data Source:  BioPlex,STRINGDB
MANEA
Tbio
Family:  Enzyme
Novelty:  0.03693244
p_int:  0.928753666
p_ni:  0.071241822
p_wrong:  0.000004512
Score:  0.185
Data Source:  BioPlex,STRINGDB
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.861712881
p_ni:  0.138285872
p_wrong:  0.000001247
Score:  0.158
Data Source:  BioPlex,STRINGDB
KIRREL1
Tbio
Novelty:  0.03216031
p_int:  0.79191401
p_ni:  0.20808599
Score:  0.203
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.785417636
p_ni:  0.214582364
Score:  0.2
Data Source:  BioPlex,STRINGDB
TMTC3
Tdark
Novelty:  0.17411457
p_int:  0.77093887
p_ni:  0.229061129
p_wrong:  1e-9
Score:  0.259
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
3
2
3
55.8
risk-taking behaviour
1
1
1
46.1
depressive symptom measurement
1
1
1
42.3
neuroticism measurement
1
1
1
42.3
smoking status measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
3
55.8
risk-taking behaviour
1
46.1
depressive symptom measurement
1
42.3
neuroticism measurement
1
42.3
smoking status measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyrotropin releasing hormone degrading enzyme
VGNC:8586
467071
Macaque
thyrotropin releasing hormone degrading enzyme
717653
Mouse
MGI:2384311
237553
Rat
RGD:728895
366894
Dog
thyrotropin releasing hormone degrading enzyme
VGNC:47798
481166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyrotropin releasing hormone degrading enzyme
Macaque
thyrotropin releasing hormone degrading enzyme
Mouse
Rat
Dog
thyrotropin releasing hormone degrading enzyme
Publication Statistics
PubMed Score 43.24
PubMed score by year
PubTator Score 35.92
PubTator score by year
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Related Publications
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PMID
Year
Title