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Tbio
IKZF3
Zinc finger protein Aiolos

Protein Summary
Description
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different iso ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293068
  • ENSP00000462791
  • ENSG00000161405
  • ENST00000346243
  • ENSP00000341977
  • ENST00000346872
  • ENSP00000344544
  • ENST00000350532
  • ENSP00000344471
  • ENST00000351680
  • ENSP00000345622
  • ENST00000377944
  • ENSP00000367179
  • ENST00000377945
  • ENSP00000367180
  • ENST00000377952
  • ENSP00000367188
  • ENST00000377958
  • ENSP00000367194
  • ENST00000394189
  • ENSP00000377741
  • ENST00000439016
  • ENSP00000403027
  • ENST00000439167
  • ENSP00000403776
  • ENST00000467757
  • ENSP00000420463
  • ENST00000535189
  • ENSP00000438972
  • ENST00000583368
  • ENSP00000462452
  • ENST00000623724
  • ENSP00000485515

Symbol
  • ZNFN1A3
  • AIO
  • AIOLOS
  • ZNFN1A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.81
transcription factor
0.71
phenotype
0.7
transcription factor binding site profile
0.64
biological process
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.91   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 429   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.91   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 429   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0