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Tbio
FBXO5
F-box only protein 5

Protein Summary
Description
Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:23708605, PubMed:23708001, PubMed:16921029). Plays a role in genome integrity preservation by coord ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229758
  • ENSP00000229758
  • ENSG00000112029
  • ENST00000367241
  • ENSP00000356210

Symbol
  • EMI1
  • FBX5
  • EMI1
  • FBX5
  • Fbxo31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
kinase perturbation
0.93
histone modification site profile
0.75
transcription factor binding site profile
0.73
PubMedID
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.06   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.06   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (245)
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999999995
p_ni:  5e-9
Score:  0.969
Data Source:  BioPlex,Reactome,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999992
p_ni:  6e-9
p_wrong:  2e-9
Score:  0.973
Data Source:  BioPlex,Reactome,STRINGDB
FZR1
Tbio
Novelty:  0.01599606
p_int:  0.99999999
p_ni:  1e-8
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
CDC26
Tbio
Family:  Enzyme
Novelty:  0.07456358
p_int:  0.999998323
p_ni:  0.000001677
Score:  0.991
Data Source:  BioPlex,STRINGDB
ANAPC16
Tdark
Family:  Enzyme
Novelty:  0.06353035
p_int:  0.999998065
p_ni:  0.000001913
p_wrong:  2.2e-8
Score:  0.911
Data Source:  BioPlex,STRINGDB
ANAPC5
Tbio
Family:  Enzyme
Novelty:  0.02102572
p_int:  0.999996927
p_ni:  8.85e-7
p_wrong:  0.000002188
Score:  0.924
Data Source:  BioPlex,STRINGDB
ANAPC13
Tbio
Family:  Enzyme
Novelty:  0.06125489
p_int:  0.998587254
p_ni:  2.45e-7
p_wrong:  0.001412501
Score:  0.983
Data Source:  BioPlex,STRINGDB
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.959010496
p_ni:  0.040989504
Score:  0.936
Data Source:  BioPlex,STRINGDB
CDC20
Tbio
Novelty:  0.00197887
Score:  0.999
Data Source:  Reactome,STRINGDB
ANAPC2
Tbio
Family:  Enzyme
Novelty:  0.19812984
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G1/S Transition
Reactome
G1/S-Specific Transcription
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
Cell Cycle
Cell Cycle, Mitotic
G1/S Transition
G1/S-Specific Transcription
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
1
1.1
78.1
mathematical ability
3
3
3
76.5
body mass index
2
2
3
60.8
self reported educational attainment
1
1
1
53.7
C-reactive protein measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1.1
78.1
mathematical ability
3
76.5
body mass index
3
60.8
self reported educational attainment
1
53.7
C-reactive protein measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 5
VGNC:2829
463083
Macaque
F-box protein 5
703219
Mouse
MGI:1914391
67141
Rat
RGD:1309405
292263
Dog
F-box protein 5
VGNC:40787
612020
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 5
Macaque
F-box protein 5
Mouse
Rat
Dog
F-box protein 5
Publication Statistics
PubMed Score 72.06
PubMed score by year
PubTator Score 43.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title