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Tbio
PACSIN3
Protein kinase C and casein kinase substrate in neurons protein 3

Protein Summary
Description
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298838
  • ENSP00000298838
  • ENSG00000165912
  • ENST00000539589
  • ENSP00000440945

Symbol
  • SDPIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
ligand (protein) perturbation
0.83
transcription factor
0.68
gene perturbation
0.66
cellular component
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
1
8.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C and casein kinase substrate in neurons 3
VGNC:3077
451163
Macaque
protein kinase C and casein kinase substrate in neurons 3
713919
Mouse
MGI:1891410
80708
Rat
RGD:1307327
311187
Dog
protein kinase C and casein kinase substrate in neurons 3
VGNC:44233
475984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C and casein kinase substrate in neurons 3
Macaque
protein kinase C and casein kinase substrate in neurons 3
Mouse
Rat
Dog
protein kinase C and casein kinase substrate in neurons 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKS6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (165)
1 – 10 of 165
PACSIN2
Tbio
Family: Enzyme
Novelty: 0.0250489
p_int: 0.999999996
p_ni: 4e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
COBLL1
Tbio
Novelty: 0.09264701
p_int: 0.999999803
p_ni: 1.79e-7
p_wrong: 1.8e-8
Score: 0.9
Data Source: BioPlex,STRINGDB
COBL
Tbio
Novelty: 0.01903038
p_int: 0.999999773
p_ni: 2.27e-7
Score: 0.876
Data Source: BioPlex,STRINGDB
PACSIN1
Tbio
Family: Enzyme
Novelty: 0.01482925
p_int: 0.999921313
p_ni: 0.000078687
Score: 0.993
Data Source: BioPlex,STRINGDB
MICALL1
Tbio
Novelty: 0.10288314
p_int: 0.990137165
p_ni: 0.007129885
p_wrong: 0.00273295
Score: 0.322
Data Source: BioPlex,STRINGDB
RAI14
Tbio
Novelty: 0.06291577
p_int: 0.760626652
p_ni: 0.238421679
p_wrong: 0.000951668
Score: 0.844
Data Source: BioPlex,STRINGDB
DNM1
Tbio
Novelty: 0.00319082
Score: 0.965
Data Source: STRINGDB
SYNJ1
Tbio
Novelty: 0.01030746
Score: 0.96
Data Source: STRINGDB
WASL
Tbio
Novelty: 0.0029314
Score: 0.954
Data Source: STRINGDB
FNBP1L
Tbio
Novelty: 0.01235857
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.15

PubMed score by year
PubTator Score  7.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer