Protein Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]
- ENST00000335422
- ENSP00000334079
- ENSG00000167759
- ENST00000595793
- ENSP00000470555
- KLKL4
- KLKL4
- KLK-L4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.68 | ||
protein domain | 0.58 | ||
tissue | 0.58 | ||
cell line | 0.56 | ||
cell type or tissue | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.89 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 261 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.89 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 261 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (30)
SERPINE2
Novelty: 0.00246375
p_int: 0.998192293
p_ni: 0.001699715
p_wrong: 0.000107992
Score: 0.602
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (22)
Reactome (5)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Metabolism of proteins | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 3 | 5 | 91.6 | |||||
blood protein measurement | 1 | 2 | 2 | 89.8 | |||||
kallikreinâ6 measurement | 1 | 1 | 1 | 87.2 | |||||
kallikrein-11 measurement | 1 | 1 | 0 | 1.5 | 69.5 | ||||
C-reactive protein measurement | 1 | 1 | 1 | 38.8 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 91.6 | |||||
blood protein measurement | 2 | 89.8 | |||||
kallikreinâ6 measurement | 1 | 87.2 | |||||
kallikrein-11 measurement | 0 | 1.5 | 69.5 | ||||
C-reactive protein measurement | 1 | 38.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 13 | VGNC:2330 | 748200 | |||||
Mouse | MGI:3615275 | 626834 | ||||||
Rat | RGD:1309337 | 292848 | ||||||
Dog | kallikrein related peptidase 13 | VGNC:42480 | 100856194 | |||||
Horse | kallikrein related peptidase 13 | VGNC:19485 | 100067063 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | kallikrein related peptidase 13 | |||||
Horse | kallikrein related peptidase 13 | |||||
Publication Statistics
PubMed Score 48.89
PubMed score by year
PubTator Score 25.05
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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