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Tchem
KLK13
Kallikrein-13

Protein Summary
Description
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335422
  • ENSP00000334079
  • ENSG00000167759
  • ENST00000595793
  • ENSP00000470555

Symbol
  • KLKL4
  • KLKL4
  • KLK-L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.68
protein domain
0.58
tissue
0.58
cell line
0.56
cell type or tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.89   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.89   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (30)
SERPINE2
Tbio
Novelty:  0.00246375
p_int:  0.998192293
p_ni:  0.001699715
p_wrong:  0.000107992
Score:  0.602
Data Source:  BioPlex,STRINGDB
SPINK6
Tbio
Family:  Enzyme
Novelty:  0.11687263
Score:  0.949
Data Source:  Reactome,STRINGDB
IGFBP3
Tchem
Novelty:  0.0003776
Score:  0.908
Data Source:  STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.907
Data Source:  STRINGDB
IGFALS
Tbio
Novelty:  0.0287658
Score:  0.906
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.904
Data Source:  STRINGDB
SIGLEC9
Tbio
Novelty:  0.01805735
Score:  0.715
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.656
Data Source:  STRINGDB
SPINK5
Tbio
Family:  Enzyme
Novelty:  0.00451563
Score:  0.571
Data Source:  STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.56
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Reactome
Metabolism of proteins
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Metabolism of proteins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
3
5
91.6
blood protein measurement
1
2
2
89.8
kallikrein‐6 measurement
1
1
1
87.2
kallikrein-11 measurement
1
1
0
1.5
69.5
C-reactive protein measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
91.6
blood protein measurement
2
89.8
kallikrein‐6 measurement
1
87.2
kallikrein-11 measurement
0
1.5
69.5
C-reactive protein measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 13
VGNC:2330
748200
Mouse
MGI:3615275
626834
Rat
RGD:1309337
292848
Dog
kallikrein related peptidase 13
VGNC:42480
100856194
Horse
kallikrein related peptidase 13
VGNC:19485
100067063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 13
Mouse
Rat
Dog
kallikrein related peptidase 13
Horse
kallikrein related peptidase 13
Publication Statistics
PubMed Score 48.89
PubMed score by year
PubTator Score 25.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title