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Tbio
KLK12
Kallikrein-12

Protein Summary
Description
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250351
  • ENSP00000250351
  • ENSG00000186474
  • ENST00000319590
  • ENSP00000324181
  • ENST00000525263
  • ENSP00000436458
  • ENST00000529888
  • ENSP00000434036

Symbol
  • KLKL5
  • KLKL5
  • KLK-L5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.68
protein domain
0.58
transcription factor perturbation
0.47
tissue
0.45
gene perturbation
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.67   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.67   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
3
5
91.6
blood protein measurement
1
2
2
89.8
kallikrein‐6 measurement
1
1
1
87.2
kallikrein-11 measurement
1
1
0
1.5
69.5
C-reactive protein measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
91.6
blood protein measurement
2
89.8
kallikrein‐6 measurement
1
87.2
kallikrein-11 measurement
0
1.5
69.5
C-reactive protein measurement
1
38.8
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 12
VGNC:11149
748695
Macaque
kallikrein related peptidase 12
719517
Mouse
MGI:1916761
69511
Horse
kallikrein related peptidase 12
VGNC:19484
100067108
Cow
kallikrein related peptidase 12
VGNC:30674
618448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 12
Macaque
kallikrein related peptidase 12
Mouse
Horse
kallikrein related peptidase 12
Cow
kallikrein related peptidase 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKR0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (13)
1 – 10 of 13
SPINK6
Tbio
Family:  Enzyme
Novelty:  0.11687263
Score:  0.948
Data Source:  Reactome,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.668
Data Source:  STRINGDB
ZNF648
Tdark
Family:  TF
Novelty:  0.57586282
Score:  0.564
Data Source:  STRINGDB
SPINK5
Tbio
Family:  Enzyme
Novelty:  0.00451563
Score:  0.558
Data Source:  STRINGDB
TIGD7
Tdark
Novelty:  0.38962555
Score:  0.533
Data Source:  STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.517
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.474
Data Source:  STRINGDB
NTF4
Tbio
Novelty:  0.00192875
Score:  0.45
Data Source:  STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.449
Data Source:  STRINGDB
BDKRB2
Tclin
Family:  GPCR
Novelty:  0.00335227
Score:  0.448
Data Source:  STRINGDB
Publication Statistics
PubMed Score  40.67

PubMed score by year
PubTator Score  15.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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