Tchem UTS2R Urotensin-2 receptor

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Urotensin-2 Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Urotensin-2 Receptor

Protein Summary

Description

High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Uniprot Accession IDs

• Q9UKP6
• B2RMV8
• UR-2-R

Gene Name

• UTS2R

Ensembl ID

• ENST00000313135
• ENSP00000323516
• ENSG00000181408

Symbol

• GPR14
• UTR
• UTR2
• GPR14
• UR-2-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.72
gene perturbation	0.7
ligand (chemical)	0.61
biological term	0.52
cell line	0.5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.15   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.15   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 146

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (146)

Explore Active Ligands

1 – 10 of 146

CHEMBL522770

UTS2RTchem GPCR

Ki: 8.27

CHEMBL495075

UTS2RTchem GPCR

Ki: 8.39999962

CHEMBL567303,CHEMBL1164032

UTS2RTchem GPCR

Ki: 8.3

CHEMBL402303

UTS2RTchem GPCR

Ki: 8.22

CHEMBL254356

UTS2RTchem GPCR

Ki: 7.8

CHEMBL3358687

UTS2RTchem GPCR

IC50: 7.89

CHEMBL566894

UTS2RTchem GPCR

Ki: 7.19

CHEMBL3104461

UTS2RTchem GPCR

IC50: 7.22

CHEMBL404177

UTS2RTchem GPCR

Ki: 8.4

CHEMBL93758

UTS2RTchem GPCR

-: 6.4000001

Pathways (25)

Reactome (7)

KEGG (1)

WikiPathways (17)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Peptide ligand-binding receptors	189 targets	R-HSA-375276

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Peptide ligand-binding receptors	189 targets	R-HSA-375276

Gene Ontology Terms (12)

Functions (3)

Components (3)

Processes (6)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
G protein-coupled peptide receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
urotensin II receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled receptor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (198)

Explore Interacting Targets

1 – 10 of 198

• See Interactions on String-DB

UTS2

Tbio

Novelty: 0.0029971

Score: 0.994

Data Source: Reactome,STRINGDB

UTS2B

Tbio

Novelty: 0.04729463

Score: 0.987

Data Source: Reactome,STRINGDB

KISS1R

Tchem

Family: GPCR

Novelty: 0.00324819

Score: 0.957

Data Source: STRINGDB

EDN1

Tbio

Novelty: 0.000085

Score: 0.95

Data Source: STRINGDB

GPR153

Tdark

Family: GPCR

Novelty: 0.62164662

Score: 0.937

Data Source: STRINGDB

NTS

Tbio

Novelty: 0.00035891

Score: 0.935

Data Source: STRINGDB

PTGER1

Tclin

Family: GPCR

Novelty: 0.00206493

Score: 0.934

Data Source: STRINGDB

GNG3

Tbio

Novelty: 0.16248863

Score: 0.93

Data Source: STRINGDB

AVP

Tbio

Novelty: 0.0001163

Score: 0.925

Data Source: STRINGDB

NPFF

Tbio

Novelty: 0.00350925

Score: 0.922

Data Source: STRINGDB

Publication Statistics

PubMed Score  67.15

PubMed score by year

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PubTator Score  116.11

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNA

1-70

YTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFT

70-140

LTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRA

140-210

YLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLL

210-280

AQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRAR

280-350

FQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA

350-389

MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA

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Uniprot Keyword

Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer