Protein Classes
Protein Summary
High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
- ENST00000313135
- ENSP00000323516
- ENSG00000181408
- GPR14
- UTR
- UTR2
- GPR14
- UR-2-R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.72 | ||
gene perturbation | 0.7 | ||
ligand (chemical) | 0.61 | ||
biological term | 0.52 | ||
cell line | 0.5 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67.15 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67.15 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 146
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (146)
1 – 10 of 146
Pathways (25)
Reactome (7)
KEGG (1)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Gene Ontology Terms (12)
Functions (3)
Components (3)
Processes (6)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (198)
1 – 10 of 198
UTS2
Novelty: 0.0029971
Score: 0.994
Data Source: Reactome,STRINGDB
UTS2B
Novelty: 0.04729463
Score: 0.987
Data Source: Reactome,STRINGDB
KISS1R
Family: GPCR
Novelty: 0.00324819
Score: 0.957
Data Source: STRINGDB
EDN1
Novelty: 0.000085
Score: 0.95
Data Source: STRINGDB
GPR153
Family: GPCR
Novelty: 0.62164662
Score: 0.937
Data Source: STRINGDB
NTS
Novelty: 0.00035891
Score: 0.935
Data Source: STRINGDB
PTGER1
Family: GPCR
Novelty: 0.00206493
Score: 0.934
Data Source: STRINGDB
GNG3
Novelty: 0.16248863
Score: 0.93
Data Source: STRINGDB
AVP
Novelty: 0.0001163
Score: 0.925
Data Source: STRINGDB
NPFF
Novelty: 0.00350925
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score 67.15
PubMed score by year
PubTator Score 116.11
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNA
1-70
YTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFT
70-140
LTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRA
140-210
YLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLL
210-280
AQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRAR
280-350
FQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
350-389
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
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