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Tchem
UTS2R
Urotensin-2 receptor

Protein Summary
Description
High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313135
  • ENSP00000323516
  • ENSG00000181408

Symbol
  • GPR14
  • UTR
  • UTR2
  • GPR14
  • UR-2-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.72
gene perturbation
0.7
ligand (chemical)
0.61
biological term
0.52
cell line
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.74   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.74   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 206
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (198)
UTS2
Tbio
Novelty:  0.00279068
Score:  0.994
Data Source:  Reactome,STRINGDB
UTS2B
Tbio
Novelty:  0.04307669
Score:  0.987
Data Source:  Reactome,STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.957
Data Source:  STRINGDB
EDN1
Tbio
Novelty:  0.00007453
Score:  0.95
Data Source:  STRINGDB
GPR153
Tdark
Family:  GPCR
Novelty:  0.44419008
Score:  0.937
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.935
Data Source:  STRINGDB
PTGER1
Tclin
Family:  GPCR
Novelty:  0.0013716
Score:  0.934
Data Source:  STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.93
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.925
Data Source:  STRINGDB
NPFF
Tbio
Novelty:  0.00489546
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
urotensin 2 receptor
VGNC:9774
745386
Macaque
urotensin 2 receptor
574245
Mouse
MGI:2183450
217369
Rat
RGD:621884
57305
Dog
urotensin 2 receptor
VGNC:48217
491678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
urotensin 2 receptor
Macaque
urotensin 2 receptor
Mouse
Rat
Dog
urotensin 2 receptor
Publication Statistics
PubMed Score 98.74
PubMed score by year
PubTator Score 116.11
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title