Tchem UTS2R Urotensin-2 receptor

Protein Summary

Description

High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.

Uniprot Accession IDs

• Q9UKP6
• B2RMV8
• UR-2-R

Gene Name

• UTS2R

Ensembl ID

• ENST00000313135
• ENSP00000323516
• ENSG00000181408

Symbol

• GPR14
• UTR
• UTR2
• GPR14
• UR-2-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.72
gene perturbation	0.7
ligand (chemical)	0.61
biological term	0.52
cell line	0.5

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Urotensin-2 Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Urotensin-2 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.84   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.84   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 230

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0