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Tbio
ADAMTS6
A disintegrin and metalloproteinase with thrombospondin motifs 6

Protein Classes
Protein Summary
Description
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381052
  • ENSP00000424377
  • ENSG00000049192
  • ENST00000381055
  • ENSP00000370443

Symbol
  • ADAM-TS6
  • ADAMTS-6
  • ADAM-TS 6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.87
virus perturbation
0.79
transcription factor binding site profile
0.73
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.26   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.26   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
4
4
0
2.8
90.4
intraocular pressure measurement
3
4
4
88.2
appendicular lean mass
2
1
2
81.4
body height
1
2
2
71.6
corneal topography
1
1
1
58.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.8
90.4
intraocular pressure measurement
4
88.2
appendicular lean mass
2
81.4
body height
2
71.6
corneal topography
1
58.1
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (61)
1 – 10 of 61
POFUT2
Tbio
Family: Enzyme
Novelty: 0.06236603
Score: 0.921
Data Source: STRINGDB
ADAMTS13
Tbio
Family: Enzyme
Novelty: 0.0006095
Score: 0.921
Data Source: STRINGDB
ADAMTSL2
Tbio
Novelty: 0.05511648
Score: 0.92
Data Source: STRINGDB
ADAMTSL1
Tbio
Novelty: 0.08853044
Score: 0.919
Data Source: STRINGDB
ADAMTSL4
Tbio
Novelty: 0.03890484
Score: 0.918
Data Source: STRINGDB
THBS1
Tbio
Novelty: 0.00073905
Score: 0.917
Data Source: STRINGDB
ADAMTS1
Tchem
Family: Enzyme
Novelty: 0.00483758
Score: 0.916
Data Source: STRINGDB
ADAMTS3
Tbio
Family: Enzyme
Novelty: 0.00578975
Score: 0.916
Data Source: STRINGDB
ADAMTS17
Tbio
Family: Enzyme
Novelty: 0.04568792
Score: 0.915
Data Source: STRINGDB
THSD4
Tbio
Novelty: 0.12898073
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.26

PubMed score by year
PubTator Score  6.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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