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Tbio
ADAMTS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

Protein Classes
Protein Summary
Description
Metalloprotease that may play a role in the degradation of COMP. The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388820
  • ENSP00000373472
  • ENSG00000136378

Symbol
  • ADAM-TS7
  • ADAMTS-7
  • ADAM-TS 7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.83
PubMedID
0.61
biological process
0.55
disease
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.53   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.53   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
10
4
1.1
97.8
2
3
0
1.2
96
1
3
0
1.1
91.3
3
3
0
1.1
84.6
corneal topography
3
1
3
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.8
0
1.2
96
0
1.1
91.3
0
1.1
84.6
corneal topography
3
82
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 7
VGNC:11788
467749
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 7 [Source:HGNC Symbol;Acc:HGNC:223]
Mouse
MGI:1347346
108153
Rat
RGD:1306713
315879
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 7
VGNC:37603
488775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 7
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 7 [Source:HGNC Symbol;Acc:HGNC:223]
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (73)
1 – 10 of 73
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.927
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.925
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.923
Data Source:  STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.923
Data Source:  STRINGDB
ADAMTS3
Tbio
Family:  Enzyme
Novelty:  0.00578975
Score:  0.922
Data Source:  STRINGDB
ADAMTSL3
Tbio
Novelty:  0.07699522
Score:  0.921
Data Source:  STRINGDB
ADAMTS20
Tbio
Family:  Enzyme
Novelty:  0.0416108
Score:  0.921
Data Source:  STRINGDB
ADAMTS14
Tbio
Family:  Enzyme
Novelty:  0.07885034
Score:  0.92
Data Source:  STRINGDB
ADAMTS15
Tbio
Family:  Enzyme
Novelty:  0.09715925
Score:  0.92
Data Source:  STRINGDB
ADAMTS5
Tchem
Family:  Enzyme
Novelty:  0.00364004
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  60.53

PubMed score by year
PubTator Score  26.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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