You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
GTF3C4
General transcription factor 3C polypeptide 4

Protein Summary
Description
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372146
  • ENSP00000361219
  • ENSG00000125484

Symbol
  • KAT12
  • TFIII90
  • TFIIIC90
  • TFIIIC290
  • TF3C-delta
  • TFIIICDELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.97
virus perturbation
0.9
protein complex
0.77
histone modification site profile
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIIC subunit 4
VGNC:13891
744329
Macaque
general transcription factor IIIC subunit 4
714849
Mouse
MGI:2138937
269252
Rat
RGD:1592609
685539
Dog
general transcription factor IIIC subunit 4
VGNC:41554
100855968
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIIC subunit 4
Macaque
general transcription factor IIIC subunit 4
Mouse
Rat
Dog
general transcription factor IIIC subunit 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKN8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Reactome
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (63)
1 – 10 of 63
ZNF688
Tdark
Family: TF
Novelty: 0.97298734
p_int: 1
Data Source: BioPlex
CLIP2
Tbio
Novelty: 0.0326657
p_int: 0.999999998
p_wrong: 2e-9
Data Source: BioPlex
ZNF747
Tdark
Novelty: 9
p_int: 0.999999984
p_ni: 1.2e-8
p_wrong: 5e-9
Data Source: BioPlex
PABPC3
Tbio
Novelty: 0.13551529
p_int: 0.999999614
p_ni: 2.6e-8
p_wrong: 3.6e-7
Data Source: BioPlex
ZNF764
Tdark
Family: TF
Novelty: 0.76308829
p_int: 0.999994652
p_ni: 0.00000534
p_wrong: 8e-9
Data Source: BioPlex
GTF3C2
Tdark
Novelty: 0.1827844
p_int: 0.999985616
p_ni: 0.000014384
Score: 0.998
Data Source: BioPlex,STRINGDB
GTF3C1
Tbio
Novelty: 0.00580303
p_int: 0.999975154
p_ni: 0.000024846
Score: 0.997
Data Source: BioPlex,STRINGDB
GTF3C5
Tdark
Novelty: 0.38618595
p_int: 0.999960899
p_ni: 0.000039101
Score: 0.999
Data Source: BioPlex,STRINGDB
GTF3C3
Tdark
Novelty: 0.48547531
p_int: 0.999938081
p_ni: 0.000061919
Score: 0.997
Data Source: BioPlex,STRINGDB
PSME4
Tbio
Novelty: 0.01206213
p_int: 0.99993379
p_ni: 0.00006621
Data Source: BioPlex
Publication Statistics
PubMed Score  2.50

PubMed score by year
PubTator Score  0.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer