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Tbio
PRDM4
PR domain zinc finger protein 4

Protein Summary
Description
May function as a transcription factor involved in cell differentiation. The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228437
  • ENSP00000228437
  • ENSG00000110851

Symbol
  • PFM1
  • PFM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.79
transcription factor binding site profile
0.78
protein domain
0.73
kinase perturbation
0.71
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.95
Data Source:  Reactome,STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.944
Data Source:  Reactome,STRINGDB
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.943
Data Source:  Reactome,STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.939
Data Source:  Reactome,STRINGDB
NGFR
Tclin
Novelty:  0.00072052
Score:  0.908
Data Source:  Reactome,STRINGDB
SORT1
Tchem
Novelty:  0.00319862
Score:  0.9
Data Source:  STRINGDB
SMYD4
Tbio
Family:  Epigenetic
Novelty:  0.18455037
Score:  0.659
Data Source:  STRINGDB
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
Score:  0.572
Data Source:  STRINGDB
VIPAS39
Tbio
Novelty:  0.02348642
Score:  0.536
Data Source:  STRINGDB
CDS2
Tbio
Family:  Enzyme
Novelty:  0.13210626
Score:  0.502
Data Source:  STRINGDB
Pathways (6)
Death Receptor Signalling (R-HSA-73887)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Signal Transduction
Reactome
p75 NTR receptor-mediated signalling
Reactome
p75NTR negatively regulates cell cycle via SC1
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Signal Transduction
p75 NTR receptor-mediated signalling
p75NTR negatively regulates cell cycle via SC1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
64
monocyte percentage of leukocytes
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
64
monocyte percentage of leukocytes
1
4.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 4
VGNC:5544
452208
Macaque
PR/SET domain 4
704529
Mouse
MGI:1920093
72843
Rat
RGD:619929
170820
Dog
PR/SET domain 4
VGNC:44949
481291
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 4
Macaque
PR/SET domain 4
Mouse
Rat
Dog
PR/SET domain 4
Publication Statistics
PubMed Score 9.74
PubMed score by year
PubTator Score 8.37
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title