Protein Summary
Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017]
- ENST00000379442
- ENSP00000368755
- ENSG00000205277
- ENST00000536621
- ENSP00000441929
- MUC11
- MUC11
- MUC-11
- MUC-12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.61 | ||
cellular component | 0.57 | ||
cell line | 0.47 | ||
pathway | 0.35 | ||
biological term | 0.34 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.41 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 73 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.41 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 73 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (68)
Nearest Tclin Targets
Pathways (15)
Reactome (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | Dectin-2 family | ||||
Reactome | Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Reactome | Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Reactome | Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
C-type lectin receptors (CLRs) | ||||
Dectin-2 family | ||||
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | ||||
Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 96.5 | |||||
heart rate response to recovery post exercise | 5 | 2 | 5 | 81.2 | |||||
alkaline phosphatase measurement | 2 | 2 | 1 | 6.8 | 75.7 | ||||
heel bone mineral density | 2 | 2 | 2 | 57.7 | |||||
RR interval | 1 | 1 | 0 | 9 | 46.1 | ||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 96.5 | |||||
heart rate response to recovery post exercise | 5 | 81.2 | |||||
alkaline phosphatase measurement | 1 | 6.8 | 75.7 | ||||
heel bone mineral density | 2 | 57.7 | |||||
RR interval | 0 | 9 | 46.1 | ||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 20.41
PubMed score by year
PubTator Score 15.47
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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