Tbio MUC12 Mucin-12

Protein Summary

Description

Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q9UKN1
• A6ND38
• F5GWV9
• Q9UKN0
• MUC-12

Gene Name

• MUC12

Ensembl ID

• ENST00000379442
• ENSP00000368755
• ENSG00000205277
• ENST00000536621
• ENSP00000441929

Symbol

• MUC11
• MUC11
• MUC-11
• MUC-12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.61
cellular component	0.57
cell line	0.47
pathway	0.35
biological term	0.34

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.41   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.41   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	3	6		96.5
heart rate response to recovery post exercise	EFO_0009185	5	2	5		81.2
alkaline phosphatase measurement	EFO_0004533	2	2	1	6.8	75.7
heel bone mineral density	EFO_0009270	2	2	2		57.7
RR interval	EFO_0004831	1	1	0	9	46.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		96.5
heart rate response to recovery post exercise	EFO_0009185	5		81.2
alkaline phosphatase measurement	EFO_0004533	1	6.8	75.7
heel bone mineral density	EFO_0009270	2		57.7
RR interval	EFO_0004831	0	9	46.1

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Protein Structure (0 Structures, 22 AlphaFold Models)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9UKN1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)

Reactome (15)

C-type lectin receptors (CLRs) (R-HSA-5621481)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Reactome	Dectin-2 family	29 targets	R-HSA-5621480
Reactome	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Reactome	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Reactome	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Name	Explore in Pharos	Explore in Source
C-type lectin receptors (CLRs)	144 targets	R-HSA-5621481
Dectin-2 family	29 targets	R-HSA-5621480
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	20 targets	R-HSA-5083632
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19 targets	R-HSA-5083636
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19 targets	R-HSA-5083625

Gene Ontology Terms (6)

Components (3)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
Golgi lumen	Traceable Author Statement (TAS)	Reactome
plasma membrane	Traceable Author Statement (TAS)	Reactome
integral component of plasma membrane	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

MUC13

Tbio

Novelty:  0.01282861

Score:  0.979

Data Source:  STRINGDB

MUC15

Tbio

Novelty:  0.02213624

Score:  0.978

Data Source:  STRINGDB

MUC20

Tbio

Novelty:  0.04645313

Score:  0.977

Data Source:  STRINGDB

MUC6

Tbio

Novelty:  0.00304872

Score:  0.972

Data Source:  STRINGDB

MUC16

Tbio

Novelty:  0.00444587

Score:  0.972

Data Source:  STRINGDB

MUC5B

Tbio

Novelty:  0.000832

Score:  0.972

Data Source:  STRINGDB

MUC7

Tbio

Novelty:  0.00750654

Score:  0.972

Data Source:  STRINGDB

MUC21

Tbio

Novelty:  0.02583488

Score:  0.969

Data Source:  STRINGDB

MUC1

Tchem

Novelty:  0.00024203

Score:  0.969

Data Source:  STRINGDB

MUC5AC

Tbio

Novelty:  0.00074159

Score:  0.969

Data Source:  STRINGDB

Publication Statistics

PubMed Score  20.41

PubMed score by year

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PubTator Score  15.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Signal

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein A 1 measurement
body mass index
chronic kidney disease
electrocardiography
heart rate
heart rate response to exercise
heart rate response to recovery post exercise
heel bone mineral density
low density lipoprotein cholesterol measurement