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Tbio
RALY
RNA-binding protein Raly

Protein Summary
Description
RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246194
  • ENSP00000246194
  • ENSG00000125970
  • ENST00000375114
  • ENSP00000364255

Symbol
  • HNRPCL2
  • P542
  • P542
  • HNRPCL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.87
PubMedID
0.77
co-expressed gene
0.76
transcription factor
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.11   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.11   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
3
1
92.8
body mass index
1
1
1
91.5
hair colour measurement
1
1
1
89.7
cutaneous squamous cell carcinoma
2
1
1
1.3
89.5
2
1
0
1.4
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
92.8
body mass index
1
91.5
hair colour measurement
1
89.7
cutaneous squamous cell carcinoma
1
1.3
89.5
0
1.4
88.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RALY heterogeneous nuclear ribonucleoprotein
VGNC:9961
458187
Macaque
RALY heterogeneous nuclear ribonucleoprotein
713317
Mouse
MGI:97850
19383
Rat
RGD:1307228
296301
Dog
RALY heterogeneous nuclear ribonucleoprotein
VGNC:45337
485845
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RALY heterogeneous nuclear ribonucleoprotein
Macaque
RALY heterogeneous nuclear ribonucleoprotein
Mouse
Rat
Dog
RALY heterogeneous nuclear ribonucleoprotein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UKM9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (151)
1 – 10 of 151
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.999431833
p_ni: 0.000568167
Score: 0.168
Data Source: BioPlex,STRINGDB
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.995508177
p_ni: 0.004491823
Data Source: BioPlex
PSME3
Tbio
Novelty: 0.01051254
p_int: 0.99330572
p_ni: 0.00669428
Score: 0.326
Data Source: BioPlex,STRINGDB
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.990050823
p_ni: 0.009949177
Score: 0.808
Data Source: BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.979074403
p_ni: 0.020925532
p_wrong: 6.5e-8
Data Source: BioPlex
RALYL
Tbio
Novelty: 0.20992411
p_int: 0.975462162
p_ni: 0.024537809
p_wrong: 2.8e-8
Score: 0.795
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.97331814
p_ni: 0.026681859
Data Source: BioPlex
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.968036104
p_ni: 0.031963896
Score: 0.379
Data Source: BioPlex,STRINGDB
STAU1
Tbio
Novelty: 0.00565778
p_int: 0.967808323
p_ni: 0.032191676
p_wrong: 2e-9
Data Source: BioPlex
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.957929709
p_ni: 0.042070291
p_wrong: 1e-9
Score: 0.164
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.11

PubMed score by year
PubTator Score  10.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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