Tchem MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

Protein Summary

Description

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9UKM7
• Q5VSG3
• Q9BRS9
• Q9Y5K7

Gene Name

• MAN1B1

Ensembl ID

• ENST00000371589
• ENSP00000360645
• ENSG00000177239

Symbol

• MRT15
• ERMAN1
• ERManI
• MANA-ER

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
transcription factor binding site profile	0.83
histone modification site profile	0.75
tissue sample	0.67
transcription factor	0.61

Protein Classes

PANTHER Classes

Protein / Chaperone / Endoplasmic Reticulum Mannosyl-oligosaccharide 1,2-alpha-mannosidase

DTO Classes

Protein / Chaperone / Endoplasmic Reticulum Mannosyl-oligosaccharide 1,2-alpha-mannosidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.39   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.39   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0