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Tchem
MAN1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

Protein Classes
Protein Summary
Description
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371589
  • ENSP00000360645
  • ENSG00000177239

Symbol
  • MRT15
  • ERMAN1
  • ERManI
  • MANA-ER
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
transcription factor binding site profile
0.83
histone modification site profile
0.75
tissue sample
0.67
transcription factor
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.55   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.55   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
91.5
monocyte percentage of leukocytes
2
2
2
88
reticulocyte measurement
3
1
3
82.3
reticulocyte count
6
1
6
80.4
leukocyte count
2
2
3
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
91.5
monocyte percentage of leukocytes
2
88
reticulocyte measurement
3
82.3
reticulocyte count
6
80.4
leukocyte count
3
70.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 1B member 1
VGNC:8906
473099
Macaque
mannosidase alpha class 1B member 1
706918
Mouse
MGI:2684954
227619
Rat
RGD:1563595
499751
Dog
endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
480667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 1B member 1
Macaque
mannosidase alpha class 1B member 1
Mouse
Rat
Dog
endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UKM7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Defective MAN1B1 causes MRT15
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Defective MAN1B1 causes MRT15
Disease
Diseases associated with N-glycosylation of proteins
Protein-Protein Interactions (66)
1 – 10 of 66
RANBP6
Tdark
Novelty:  0.75714796
p_int:  0.905197585
p_ni:  0.094802415
Score:  0.163
Data Source:  BioPlex,STRINGDB
CCNDBP1
Tbio
Novelty:  0.01527762
p_int:  0.796004372
p_ni:  0.203995628
Score:  0.252
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.788552909
p_ni:  0.211447091
Data Source:  BioPlex
MGAT1
Tchem
Family:  Enzyme
Novelty:  0.01024931
Score:  0.953
Data Source:  STRINGDB
GANAB
Tchem
Family:  Enzyme
Novelty:  0.01211958
Score:  0.946
Data Source:  STRINGDB
MANEA
Tbio
Family:  Enzyme
Novelty:  0.03693244
Score:  0.927
Data Source:  STRINGDB
MOGS
Tbio
Family:  Enzyme
Novelty:  0.00527993
Score:  0.83
Data Source:  STRINGDB
MAN2A1
Tbio
Family:  Enzyme
Novelty:  0.03034058
Score:  0.813
Data Source:  STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.805
Data Source:  STRINGDB
RER1
Tbio
Novelty:  0.02748687
Score:  0.78
Data Source:  STRINGDB
Publication Statistics
PubMed Score  79.55

PubMed score by year
PubTator Score  21.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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