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Tbio
CASP8AP2
CASP8-associated protein 2

Protein Summary
Description
Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encodi ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
molecular function
0.86
histone modification site profile
0.8
biological process
0.79
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.66   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.66   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999475
p_ni:  1.64e-7
p_wrong:  3.61e-7
Score:  0.289
Data Source:  BioPlex,STRINGDB
SCOC
Tbio
Novelty:  0.05277646
p_int:  0.999745702
p_ni:  0.00000391
p_wrong:  0.000250388
Score:  0.219
Data Source:  BioPlex,STRINGDB
PIAS1
Tbio
Family:  TF
Novelty:  0.00987743
Score:  0.943
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.937
Data Source:  Reactome,STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.934
Data Source:  Reactome,STRINGDB
PCGF2
Tbio
Novelty:  0.02148755
Score:  0.909
Data Source:  STRINGDB
PHC1
Tbio
Novelty:  0.01530622
Score:  0.902
Data Source:  STRINGDB
PHC3
Tbio
Novelty:  0.00091911
Score:  0.902
Data Source:  STRINGDB
PHC2
Tbio
Novelty:  0.01943349
Score:  0.902
Data Source:  STRINGDB
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription cofactors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
caspase 8 associated protein 2
702294
Mouse
MGI:1349399
26885
Rat
RGD:1305771
313128
Dog
caspase 8 associated protein 2
VGNC:38737
481921
Horse
caspase 8 associated protein 2
VGNC:16072
100065766
Species
Name
OMA
EggNOG
Inparanoid
Macaque
caspase 8 associated protein 2
Mouse
Rat
Dog
caspase 8 associated protein 2
Horse
caspase 8 associated protein 2
Publication Statistics
PubMed Score 37.66
PubMed score by year
PubTator Score 33.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title