You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RCOR1
REST corepressor 1

Protein Summary
Description
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in de ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262241
  • ENSP00000262241
  • ENSG00000089902

Symbol
  • KIAA0071
  • RCOR
  • RCOR
  • COREST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.98
kinase perturbation
0.91
transcription factor binding site profile
0.91
biological process
0.83
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.58   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.58   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
64.5
platelet count
2
1
2
62.5
platelet crit
2
1
2
60.6
reticulocyte measurement
2
2
2
57.2
reticulocyte count
2
2
2
40.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
64.5
platelet count
2
62.5
platelet crit
2
60.6
reticulocyte measurement
2
57.2
reticulocyte count
2
40.5
Protein Data Bank (45)
1 – 5 of 45
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
HDACs deacetylate histones
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Factors involved in megakaryocyte development and platelet production
HDACs deacetylate histones
Hemostasis
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (202)
1 – 10 of 202
HMG20A
Tbio
Family: TF
Novelty: 0.11994252
p_int: 0.999811195
p_ni: 0.000188805
Score: 0.741
Data Source: BioPlex,STRINGDB
HMG20B
Tbio
Family: TF
Novelty: 0.05983143
p_int: 0.99968536
p_ni: 0.00031464
Score: 0.993
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999416918
p_ni: 0.000583082
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
PDGFRL
Tbio
Novelty: 0.0709225
p_int: 0.994435849
p_ni: 0.005564151
Data Source: BioPlex
DCAF12L2
Tdark
Novelty: 2.92107204
p_int: 0.993467248
p_ni: 0.006532752
Score: 0.226
Data Source: BioPlex,STRINGDB
ZSCAN5A
Tdark
Family: TF
Novelty: 2.15267128
p_int: 0.990556388
p_ni: 0.009443596
p_wrong: 1.6e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
CRYAA
Tbio
Novelty: 0.01914081
p_int: 0.98829254
p_ni: 0.01170746
Data Source: BioPlex
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.965687315
p_ni: 0.034312685
Score: 0.779
Data Source: BioPlex,STRINGDB
ECE2
Tchem
Family: Enzyme
Novelty: 0.03234301
p_int: 0.946466671
p_ni: 0.053533329
Score: 0.252
Data Source: BioPlex,STRINGDB
SNAI1
Tbio
Family: TF
Novelty: 0.00040495
p_int: 0.937050558
p_ni: 0.062949442
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  128.58

PubMed score by year
PubTator Score  64.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: