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Tbio
NXT1
NTF2-related export protein 1

Protein Summary
Description
Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602). The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254998
  • ENSP00000254998
  • ENSG00000132661

Symbol
  • P15
  • MTR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
histone modification site profile
0.88
disease perturbation
0.83
transcription factor binding site profile
0.8
transcription factor
0.6


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear transport factor 2 like export factor 1
VGNC:9906
458138
Macaque
nuclear transport factor 2 like export factor 1
711846
Mouse
MGI:1929619
56488
Rat
RGD:1309327
296219
Cow
nuclear transport factor 2 like export factor 1
VGNC:32384
520351
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear transport factor 2 like export factor 1
Macaque
nuclear transport factor 2 like export factor 1
Mouse
Rat
Cow
nuclear transport factor 2 like export factor 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UKK6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Transport of Mature Transcript to Cytoplasm
Reactome
Transport of Mature mRNA derived from an Intron-Containing Transcript
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Transport of Mature Transcript to Cytoplasm
Transport of Mature mRNA derived from an Intron-Containing Transcript
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (126)
1 – 10 of 126
NXF1
Tbio
Novelty: 0.00642439
p_int: 0.999987243
p_ni: 0.000011922
p_wrong: 8.35e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.999738265
p_ni: 0.000254752
p_wrong: 0.000006982
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
NXF3
Tbio
Novelty: 0.16514217
p_int: 0.999501172
p_ni: 0.000498789
p_wrong: 3.9e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
BZW2
Tbio
Novelty: 0.17006204
p_int: 0.836165012
p_ni: 0.006593725
p_wrong: 0.157241263
Score: 0.207
Data Source: BioPlex,STRINGDB
NXF5
Tbio
Novelty: 0.18468434
Score: 0.992
Data Source: STRINGDB
ALYREF
Tbio
Novelty: 0.00523802
Score: 0.982
Data Source: STRINGDB
DDX39B
Tbio
Family: Enzyme
Novelty: 0.012548
Score: 0.974
Data Source: STRINGDB
NUP62
Tbio
Novelty: 0.01432724
Score: 0.974
Data Source: STRINGDB
THOC5
Tbio
Novelty: 0.04618391
Score: 0.971
Data Source: STRINGDB
GLE1
Tbio
Novelty: 0.01655737
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.20

PubMed score by year
PubTator Score  45.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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