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Tchem
PARP4
Poly [ADP-ribose] polymerase 4

Protein Summary
Description
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381989
  • ENSP00000371419
  • ENSG00000102699

Symbol
  • ADPRTL1
  • KIAA0177
  • PARPL
  • PH5P
  • p193
  • ARTD4
  • PARPL
  • VPARP
  • VWA5C
  • PARP-4
  • VAULT3
  • ADPRTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
protein domain
0.73
histone modification site profile
0.71
virus
0.66
tissue sample
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.92   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.92   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
rucaparib
chemical structure image
niraparib
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 4
VGNC:7300
452486
Mouse
MGI:2685589
328417
Horse
poly(ADP-ribose) polymerase family member 4
100053202
Cow
poly(ADP-ribose) polymerase family member 4
615359
Pig
poly(ADP-ribose) polymerase family member 4
100738726
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(ADP-ribose) polymerase family member 4
Mouse
Horse
poly(ADP-ribose) polymerase family member 4
Cow
poly(ADP-ribose) polymerase family member 4
Pig
poly(ADP-ribose) polymerase family member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKK3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (53)
1 – 10 of 53
MVP
Tbio
Novelty: 0.00380277
p_int: 0.999991674
p_ni: 2.25e-7
p_wrong: 0.0000081
Score: 0.965
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
TEP1
Tbio
Family: Enzyme
Novelty: 0.01254647
Score: 0.872
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.836
Data Source: STRINGDB
CASP7
Tchem
Family: Enzyme
Novelty: 0.00126224
Score: 0.826
Data Source: STRINGDB
CASP9
Tchem
Family: Enzyme
Novelty: 0.00023687
Score: 0.825
Data Source: STRINGDB
PARG
Tchem
Family: Enzyme
Novelty: 0.00424731
Score: 0.804
Data Source: STRINGDB
GZMB
Tchem
Family: Enzyme
Novelty: 0.00052869
Score: 0.8
Data Source: STRINGDB
PARP10
Tchem
Family: Enzyme
Novelty: 0.03713719
Score: 0.683
Data Source: STRINGDB
PARP6
Tchem
Family: Enzyme
Novelty: 0.10074447
Score: 0.676
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.92

PubMed score by year
PubTator Score  27.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer