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Tdark
GPATCH8
G patch domain-containing protein 8

Protein Summary
Description
The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000587228
  • ENSP00000468719
  • ENSG00000186566
  • ENST00000591680
  • ENSP00000467556

Symbol
  • GPATC8
  • KIAA0553
  • GPATC8
  • KIAA0553
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
disease perturbation
0.98
virus perturbation
0.94
cell line
0.71
microRNA
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.42   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.42   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
4
96.4
platelet count
3
3
4
2.4
93.6
platelet crit
2
2
3
72.6
progranulin measurement
1
1
1
60.2
pulse pressure measurement
1
1
1
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
96.4
platelet count
4
2.4
93.6
platelet crit
3
72.6
progranulin measurement
1
60.2
pulse pressure measurement
1
17.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G-patch domain containing 8
VGNC:9307
468276
Macaque
G-patch domain containing 8
715068
Mouse
MGI:1918667
237943
Rat
RGD:1596463
685233
Dog
G-patch domain containing 8
VGNC:41369
480500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G-patch domain containing 8
Macaque
G-patch domain containing 8
Mouse
Rat
Dog
G-patch domain containing 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (66)
1 – 10 of 66
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.999999632
p_ni:  3.68e-7
Score:  0.22
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.999999083
p_ni:  9.17e-7
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999997096
p_ni:  0.000002904
Data Source:  BioPlex
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.999994711
p_ni:  0.000005289
Score:  0.699
Data Source:  BioPlex,STRINGDB
EPB41L2
Tbio
Novelty:  0.0311733
p_int:  0.999962972
p_ni:  0.000037028
Data Source:  BioPlex
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999941902
p_ni:  0.000058096
p_wrong:  2e-9
Data Source:  BioPlex
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.999939466
p_ni:  0.000060534
Data Source:  BioPlex
U2AF2
Tbio
Novelty:  0.00590935
p_int:  0.999087867
p_ni:  0.000912133
Score:  0.368
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.999003958
p_ni:  0.000996041
p_wrong:  1e-9
Data Source:  BioPlex
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.998883283
p_ni:  0.001116717
Score:  0.597
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.42

PubMed score by year
PubTator Score  2.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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