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Tbio
PILRB
Paired immunoglobulin-like type 2 receptor beta

Protein Summary
Description
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448382
  • ENSP00000415775
  • ENSG00000121716
  • ENST00000452089
  • ENSP00000391748
  • ENST00000609309
  • ENSP00000477365

Symbol
  • FDFACT
  • FDFACT1
  • FDFACT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
kinase perturbation
0.76
cell type or tissue
0.75
virus perturbation
0.72
tissue sample
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.28   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.28   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
64.2
hemoglobin measurement
1
1
1
49.1
electrocardiography
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
64.2
hemoglobin measurement
1
49.1
electrocardiography
1
8.1
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
paired immunoglobin like type 2 receptor alpha
100137734
Species
Name
OMA
EggNOG
Inparanoid
Cow
paired immunoglobin like type 2 receptor alpha
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UKJ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (20)
1 – 10 of 20
PILRA
Tbio
Novelty: 0.05154386
p_int: 0.999998942
p_ni: 4e-9
p_wrong: 0.000001054
Data Source: BioPlex
LAIR1
Tbio
Novelty: 0.0133817
Score: 0.725
Data Source: STRINGDB
KLRG1
Tbio
Novelty: 0.00595767
Score: 0.686
Data Source: STRINGDB
C7orf61
Tdark
Novelty: 3.9028559
Score: 0.642
Data Source: STRINGDB
CD300C
Tbio
Novelty: 0.00341957
Score: 0.608
Data Source: STRINGDB
ZCWPW1
Tbio
Family: Epigenetic
Novelty: 0.11264543
Score: 0.589
Data Source: STRINGDB
TRIM4
Tbio
Family: Enzyme
Novelty: 0.11398363
Score: 0.558
Data Source: STRINGDB
LILRB1
Tbio
Novelty: 0.00463824
Score: 0.543
Data Source: STRINGDB
CASTOR3
Tdark
Novelty: 0.01099717
Score: 0.53
Data Source: STRINGDB
NYAP1
Tdark
Family: Enzyme
Novelty: 0.57209235
Score: 0.52
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.28

PubMed score by year
PubTator Score  4.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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