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Tbio
POU2F3
POU domain, class 2, transcription factor 3

Protein Summary
Description
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen. This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260264
  • ENSP00000260264
  • ENSG00000137709
  • ENST00000543440
  • ENSP00000441687

Symbol
  • OTF11
  • PLA1
  • PLA1
  • OCT11
  • PLA-1
  • Epoc-1
  • OCT-11
  • OTF-11
  • Skn-1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
disease perturbation
0.83
molecular function
0.81
biological process
0.78
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.11   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.11   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
1
3
88.2
1
1
0
1.1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
88.2
0
1.1
1.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 2 homeobox 3
VGNC:1044
745710
Macaque
POU class 2 homeobox 3
711854
Mouse
MGI:102565
18988
Rat
RGD:621691
116544
Dog
POU class 2 homeobox 3
VGNC:44828
610476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 2 homeobox 3
Macaque
POU class 2 homeobox 3
Mouse
Rat
Dog
POU class 2 homeobox 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKI9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (60)
1 – 10 of 60
DCAF11
Tbio
Novelty: 0.08318661
Score: 0.818
Data Source: STRINGDB
HCFC1
Tbio
Novelty: 0.00440762
Score: 0.813
Data Source: STRINGDB
HCFC2
Tbio
Novelty: 0.12260416
Score: 0.8
Data Source: STRINGDB
LIPG
Tchem
Family: Enzyme
Novelty: 0.00412129
Score: 0.757
Data Source: STRINGDB
LIPH
Tbio
Family: Enzyme
Novelty: 0.00961658
Score: 0.754
Data Source: STRINGDB
SPRR2A
Tbio
Novelty: 0.07065019
Score: 0.752
Data Source: STRINGDB
PLA1A
Tbio
Family: Enzyme
Novelty: 0.01478677
Score: 0.72
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.71
Data Source: STRINGDB
DDHD1
Tbio
Family: Enzyme
Novelty: 0.05209502
Score: 0.696
Data Source: STRINGDB
ELF3
Tbio
Family: TF
Novelty: 0.00284335
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  436.11

PubMed score by year
PubTator Score  256.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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