You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
TLK1
Serine/threonine-protein kinase tousled-like 1

Protein Summary
Description
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360843
  • ENSP00000354089
  • ENSG00000198586
  • ENST00000431350
  • ENSP00000411099
  • ENST00000434911
  • ENSP00000409222
  • ENST00000521943
  • ENSP00000428113

Symbol
  • KIAA0137
  • PKU-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
molecular function
0.91
transcription factor perturbation
0.8
microRNA
0.76
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.84   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.84   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (49)
TLK2
Tchem
Family:  Kinase
Novelty:  0.07082609
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.868
Data Source:  BioPlex,STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
p_int:  0.999999774
p_ni:  2.26e-7
Score:  0.98
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.999999612
p_ni:  3.88e-7
p_wrong:  1e-9
Data Source:  BioPlex
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.999999512
p_ni:  4.88e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
TNNT1
Tbio
Novelty:  0.00072003
p_int:  0.999792249
p_ni:  0.000207736
p_wrong:  1.6e-8
Data Source:  BioPlex
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  0.986888443
p_ni:  0.013111556
p_wrong:  2e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
HLF
Tbio
Family:  TF
Novelty:  0.03907097
p_int:  0.979793251
p_ni:  0.017445324
p_wrong:  0.002761425
Score:  0.485
Data Source:  BioPlex,STRINGDB
RAD9A
Tbio
Novelty:  0.00560195
Score:  0.814
Data Source:  STRINGDB
MCM7
Tbio
Novelty:  0.0017984
Score:  0.708
Data Source:  STRINGDB
MDC1
Tbio
Novelty:  0.00533097
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
DNA Damage Response
WikiPathways
ATM Signaling Pathway
WikiPathways
miRNA Regulation of DNA Damage Response
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
Name
Explore in Pharos
Explore in Source
DNA Damage Response
ATM Signaling Pathway
miRNA Regulation of DNA Damage Response
Pathways Affected in Adenoid Cystic Carcinoma
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
2
2
83.2
BMI-adjusted hip circumference
2
4
4
72.2
mean platelet volume
2
2
2
65.4
alkaline phosphatase measurement
1
1
1
60.5
mathematical ability
2
2
2
53.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
83.2
BMI-adjusted hip circumference
4
72.2
mean platelet volume
2
65.4
alkaline phosphatase measurement
1
60.5
mathematical ability
2
53.1
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tousled like kinase 1
VGNC:2881
459729
Macaque
tousled like kinase 1
694298
Mouse
MGI:2441683
228012
Dog
tousled like kinase 1
VGNC:47398
100856355
Horse
tousled like kinase 1
VGNC:24131
100052963
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tousled like kinase 1
Macaque
tousled like kinase 1
Mouse
Dog
tousled like kinase 1
Horse
tousled like kinase 1
Publication Statistics
PubMed Score 33.84
PubMed score by year
PubTator Score 18.11
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title