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Tchem
TLK1
Serine/threonine-protein kinase tousled-like 1

Protein Summary
Description
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360843
  • ENSP00000354089
  • ENSG00000198586
  • ENST00000431350
  • ENSP00000411099
  • ENST00000434911
  • ENSP00000409222
  • ENST00000521943
  • ENSP00000428113

Symbol
  • KIAA0137
  • PKU-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
molecular function
0.91
transcription factor perturbation
0.8
microRNA
0.76
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL388978
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
2
2
88.7
mathematical ability
2
2
2
80.1
C-reactive protein measurement
1
1
1
73.6
mean platelet volume
1
1
1
66.2
appendicular lean mass
2
1
2
51.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
88.7
mathematical ability
2
80.1
C-reactive protein measurement
1
73.6
mean platelet volume
1
66.2
appendicular lean mass
2
51.3
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
DNA Damage Response
WikiPathways
ATM Signaling Pathway
WikiPathways
miRNA Regulation of DNA Damage Response
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
Name
Explore in Pharos
Explore in Source
DNA Damage Response
ATM Signaling Pathway
miRNA Regulation of DNA Damage Response
Pathways Affected in Adenoid Cystic Carcinoma
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (49)
1 – 10 of 49
TLK2
Tchem
Family: Kinase
Novelty: 0.07082609
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.868
Data Source: BioPlex,STRINGDB
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.999999774
p_ni: 2.26e-7
Score: 0.98
Data Source: BioPlex,STRINGDB
SPATA1
Tdark
p_int: 0.999999612
p_ni: 3.88e-7
p_wrong: 1e-9
Data Source: BioPlex
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.999999512
p_ni: 4.88e-7
Score: 0.992
Data Source: BioPlex,STRINGDB
TNNT1
Tbio
Novelty: 0.00072003
p_int: 0.999792249
p_ni: 0.000207736
p_wrong: 1.6e-8
Data Source: BioPlex
BATF3
Tbio
Family: TF
Novelty: 0.01554987
p_int: 0.986888443
p_ni: 0.013111556
p_wrong: 2e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
HLF
Tbio
Family: TF
Novelty: 0.03907097
p_int: 0.979793251
p_ni: 0.017445324
p_wrong: 0.002761425
Score: 0.485
Data Source: BioPlex,STRINGDB
RAD9A
Tbio
Novelty: 0.00560195
Score: 0.814
Data Source: STRINGDB
MCM7
Tbio
Novelty: 0.0017984
Score: 0.708
Data Source: STRINGDB
MDC1
Tbio
Novelty: 0.00533097
Score: 0.685
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.28

PubMed score by year
PubTator Score  18.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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