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Tbio
CROT
Peroxisomal carnitine O-octanoyltransferase

Protein Summary
Description
Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331536
  • ENSP00000331981
  • ENSG00000005469
  • ENST00000412227
  • ENSP00000404867
  • ENST00000419147
  • ENSP00000413575

Symbol
  • COT
  • COT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.85
transcription factor perturbation
0.8
microRNA
0.66
biological process
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.29   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.29   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnitine O-octanoyltransferase
VGNC:4323
463514
Macaque
carnitine O-octanoyltransferase
706186
Mouse
MGI:1921364
74114
Rat
RGD:70908
83842
Dog
carnitine O-octanoyltransferase
VGNC:39627
482283
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnitine O-octanoyltransferase
Macaque
carnitine O-octanoyltransferase
Mouse
Rat
Dog
carnitine O-octanoyltransferase
Pathways (9)
Beta-oxidation of pristanoyl-CoA (R-HSA-389887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of pristanoyl-CoA
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of pristanoyl-CoA
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Protein-Protein Interactions (91)
1 – 10 of 91
CD36
Tbio
Novelty: 0.00140825
p_int: 0.999585362
p_ni: 0.000001172
p_wrong: 0.000413466
Score: 0.269
Data Source: BioPlex,STRINGDB
KLHDC4
Tdark
Novelty: 0.94196365
p_int: 0.998419702
p_ni: 0.00000291
p_wrong: 0.001577389
Score: 0.485
Data Source: BioPlex,STRINGDB
USP25
Tbio
Family: Enzyme
Novelty: 0.03671706
p_int: 0.976990529
p_ni: 0.023009461
p_wrong: 1e-8
Score: 0.323
Data Source: BioPlex,STRINGDB
FBP1
Tchem
Family: Enzyme
Novelty: 0.0029987
p_int: 0.969960459
p_ni: 0.030036216
p_wrong: 0.000003325
Score: 0.228
Data Source: BioPlex,STRINGDB
EIF2AK4
Tchem
Family: Kinase
Novelty: 0.00241683
p_int: 0.959626683
p_ni: 0.040373317
Score: 0.261
Data Source: BioPlex,STRINGDB
GATAD2B
Tbio
Family: TF
Novelty: 0.056775
p_int: 0.811752218
p_ni: 0.188247775
p_wrong: 7e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
ACOX3
Tbio
Family: Enzyme
Novelty: 0.04077258
Score: 0.971
Data Source: STRINGDB
LONP2
Tbio
Family: Enzyme
Novelty: 0.04499043
Score: 0.959
Data Source: STRINGDB
PIPOX
Tbio
Family: Enzyme
Novelty: 0.04107707
Score: 0.958
Data Source: STRINGDB
ECH1
Tbio
Family: Enzyme
Novelty: 0.02471875
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  50.29

PubMed score by year
PubTator Score  10.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer