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Tbio
SLC13A4
Solute carrier family 13 member 4

Protein Summary
Description
Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354042
  • ENSP00000297282
  • ENSG00000164707

Symbol
  • SUT1
  • NAS2
  • SUT1
  • SUT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
gene perturbation
0.65
tissue
0.52
cell line
0.49
PubMedID
0.49


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 13 member 4
VGNC:8756
738224
Macaque
solute carrier family 13 member 4
708744
Mouse
MGI:2442367
243755
Rat
RGD:1359715
503568
Dog
solute carrier family 13 member 4
VGNC:46230
610242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 13 member 4
Macaque
solute carrier family 13 member 4
Mouse
Rat
Dog
solute carrier family 13 member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKG4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (39)
1 – 10 of 39
SLC5A12
Tdark
Family: Transporter
Novelty: 0.12119749
Score: 0.77
Data Source: STRINGDB
SLC26A3
Tbio
Family: Transporter
Novelty: 0.00157687
Score: 0.74
Data Source: STRINGDB
PSMD9
Tbio
Family: Enzyme
Novelty: 0.02173534
Score: 0.718
Data Source: STRINGDB
SLC5A2
Tclin
Family: Transporter
Novelty: 0.00066797
Score: 0.697
Data Source: STRINGDB
AGXT2
Tbio
Family: Enzyme
Novelty: 0.02018289
Score: 0.681
Data Source: STRINGDB
PAAF1
Tbio
Family: Enzyme
Novelty: 0.03229774
Score: 0.675
Data Source: STRINGDB
SLC26A2
Tbio
Family: Transporter
Novelty: 0.00325201
Score: 0.671
Data Source: STRINGDB
SLC5A11
Tchem
Family: Transporter
Novelty: 0.01085543
Score: 0.6
Data Source: STRINGDB
SLC25A28
Tbio
Family: Transporter
Novelty: 0.05050869
Score: 0.594
Data Source: STRINGDB
SLC25A29
Tbio
Family: Transporter
Novelty: 0.02747809
Score: 0.58
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.25

PubMed score by year
PubTator Score  19.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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