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Tbio
APPL1
DCC-interacting protein 13-alpha

Protein Summary
Description
Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway. The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288266
  • ENSP00000288266
  • ENSG00000157500
  • ENST00000650354
  • ENSP00000498115

Symbol
  • APPL
  • DIP13A
  • KIAA1428
  • APPL
  • MODY14
  • DIP13alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.91
transcription factor perturbation
0.8
histone modification site profile
0.79
hub protein
0.75
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.7   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.7   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Programmed Cell Death
Protein-Protein Interactions (189)
1 – 10 of 189
APPL2
Tbio
Novelty: 0.18610793
p_int: 1
Score: 0.531
Data Source: BioPlex,STRINGDB
ZNF830
Tdark
Novelty: 0.38957008
p_int: 0.998266313
p_ni: 0.001567216
p_wrong: 0.000166471
Score: 0.197
Data Source: BioPlex,STRINGDB
C16orf70
Tdark
Novelty: 2.12573065
p_int: 0.998233981
p_ni: 0.001766019
Score: 0.207
Data Source: BioPlex,STRINGDB
TPCN2
Tchem
Family: IC
Novelty: 0.01351129
p_int: 0.947910813
p_ni: 0.052089187
Score: 0.258
Data Source: BioPlex,STRINGDB
FAM167A
Tbio
Novelty: 0.05232679
p_int: 0.890448197
p_ni: 0.109551803
Data Source: BioPlex
KLHL2
Tbio
Novelty: 0.07279226
p_int: 0.849543219
p_ni: 0.150456781
Score: 0.173
Data Source: BioPlex,STRINGDB
GIPC2
Tdark
Novelty: 0.21044026
p_int: 0.844490038
p_ni: 0.155509962
Score: 0.496
Data Source: BioPlex,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.987
Data Source: STRINGDB
ADIPOR1
Tbio
Novelty: 0.00273623
Score: 0.982
Data Source: STRINGDB
ADIPOR2
Tbio
Novelty: 0.00330423
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.70

PubMed score by year
PubTator Score  89.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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