Tbio APPL1 DCC-interacting protein 13-alpha

Protein Summary

Description

Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway. The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UKG1
• Q9P2B9
• Dip13-alpha

Gene Name

• APPL1

Ensembl ID

• ENST00000288266
• ENSP00000288266
• ENSG00000157500
• ENST00000650354
• ENSP00000498115

Symbol

• APPL
• DIP13A
• KIAA1428
• APPL
• MODY14
• DIP13alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.91
transcription factor perturbation	0.8
histone modification site profile	0.79
hub protein	0.75
tissue sample	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.36   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.36   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0