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Tbio
FBXL2
F-box/LRR-repeat protein 2

Protein Summary
Description
Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By simil ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000484457
  • ENSP00000417601
  • ENSG00000153558
  • ENST00000538892
  • ENSP00000441228

Symbol
  • FBL2
  • FBL3
  • FBL2
  • FBL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
microRNA
0.56
cell type or tissue
0.52
small molecule perturbation
0.52
histone modification site profile
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
55.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 2
VGNC:11394
460256
Mouse
MGI:1919429
72179
Rat
RGD:1562243
363156
Dog
F-box and leucine rich repeat protein 2
VGNC:52879
485573
Horse
F-box and leucine rich repeat protein 2
VGNC:52384
100056080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 2
Mouse
Rat
Dog
F-box and leucine rich repeat protein 2
Horse
F-box and leucine rich repeat protein 2
Protein-Protein Interactions (87)
1 – 10 of 87
YPEL3
Tbio
Novelty: 0.12550227
p_int: 0.999924038
p_ni: 7.1e-8
p_wrong: 0.000075892
Score: 0.69
Data Source: BioPlex,STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999228803
p_ni: 2.74e-7
p_wrong: 0.000770923
Score: 0.97
Data Source: BioPlex,STRINGDB
YPEL1
Tbio
Novelty: 0.17068379
p_int: 0.996127752
p_ni: 1.52e-7
p_wrong: 0.003872095
Score: 0.423
Data Source: BioPlex,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.97
Data Source: STRINGDB
FBXL3
Tbio
Novelty: 0.05042679
Score: 0.953
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.949
Data Source: STRINGDB
FBXO9
Tbio
Novelty: 0.2145394
Score: 0.944
Data Source: STRINGDB
FBXO4
Tbio
Novelty: 0.06891705
Score: 0.941
Data Source: STRINGDB
CCNF
Tbio
Novelty: 0.01288697
Score: 0.94
Data Source: STRINGDB
FBXW7
Tbio
Novelty: 0.00180856
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.47

PubMed score by year
PubTator Score  14.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer