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Tbio
FBXW11
F-box/WD repeat-containing protein 11

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265094
  • ENSP00000265094
  • ENSG00000072803
  • ENST00000296933
  • ENSP00000296933
  • ENST00000393802
  • ENSP00000377391

Symbol
  • BTRCP2
  • FBW1B
  • FBXW1B
  • KIAA0696
  • Hos
  • BTRC2
  • FBW1B
  • Fbw11
  • BTRCP2
  • FBXW1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
kinase perturbation
0.98
protein domain
0.92
biological process
0.91
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.95   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.95   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (72)
Activation of NF-kappaB in B cells (R-HSA-1169091)

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Items per page:
1 – 5 of 48
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Protein-Protein Interactions (466)
1 – 10 of 466
BTRC
Tbio
Novelty: 0.00293475
p_int: 1
Score: 0.966
Data Source: BioPlex,STRINGDB
KHDRBS2
Tbio
Novelty: 0.01986638
p_int: 0.999999519
p_ni: 4.81e-7
Score: 0.152
Data Source: BioPlex,STRINGDB
SUN2
Tbio
Novelty: 0.01387591
p_int: 0.999996736
p_ni: 0.000003264
Score: 0.297
Data Source: BioPlex,STRINGDB
APC
Tbio
Novelty: 0.00168376
p_int: 0.999995833
p_ni: 0.000004167
Score: 0.285
Data Source: BioPlex,STRINGDB
HIVEP1
Tbio
Family: TF
Novelty: 0.03053678
p_int: 0.999992121
p_ni: 0.000007762
p_wrong: 1.17e-7
Score: 0.687
Data Source: BioPlex,STRINGDB
TSC22D4
Tbio
Family: TF
Novelty: 0.25451456
p_int: 0.999991838
p_ni: 0.000008162
Data Source: BioPlex
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.999987887
p_ni: 0.000012113
Data Source: BioPlex
CDC34
Tbio
Novelty: 0.00650407
p_int: 0.999986422
p_ni: 0.000013578
Score: 0.944
Data Source: BioPlex,STRINGDB
ZNF704
Tdark
Novelty: 0.34442716
p_int: 0.999983661
p_ni: 0.000016339
Score: 0.168
Data Source: BioPlex,STRINGDB
RBMXL1
Tdark
Novelty: 0.81422952
p_int: 0.999975073
p_ni: 0.000024927
Data Source: BioPlex
Publication Statistics
PubMed Score  13.95

PubMed score by year
PubTator Score  13.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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