Tbio PTBP2 Polypyrimidine tract-binding protein 2

Protein Summary

Description

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9UKA9
• Q8N0Z1
• Q8N160
• Q8NFB0
• Q8NFB1
• Q969N9
• Q96Q76

Gene Name

• PTBP2

Ensembl ID

• ENST00000370197
• ENSP00000359216
• ENSG00000117569
• ENST00000370198
• ENSP00000359217
• ENST00000426398
• ENSP00000412788
• ENST00000609116
• ENSP00000477024

Symbol

• NPTB
• PTB
• PTBLP
• nPTB
• PTBLP
• brPTB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.9
PubMedID	0.7
gene perturbation	0.69
cell type or tissue	0.67
microRNA	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.73   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.73   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0