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Tbio
USP21
Ubiquitin carboxyl-terminal hydrolase 21

Protein Summary
Description
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909). This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289865
  • ENSP00000289865
  • ENSG00000143258
  • ENST00000368001
  • ENSP00000356980
  • ENST00000368002
  • ENSP00000356981

Symbol
  • USP23
  • USP16
  • USP23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
biological process
0.75
cell type or tissue
0.74
molecular function
0.73
transcription factor binding site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.76   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.76   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
UBC
Tbio
Novelty:  0.00204643
Score:  0.994
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.993
Data Source:  Reactome,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.992
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.99
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.99
Data Source:  STRINGDB
IL33
Tbio
Novelty:  0.00072064
Score:  0.968
Data Source:  Reactome,STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.95
Data Source:  Reactome,STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.945
Data Source:  Reactome,STRINGDB
USP16
Tbio
Family:  Enzyme
Novelty:  0.13211126
Score:  0.94
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Regulation of TNFR1 signaling
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Regulation of TNFR1 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
93
serum non-albumin protein measurement
1
2
2
84.7
blood metabolite measurement
2
2
2
83
4
2
0
1.1
82.8
childhood onset asthma
1
1
0
1.1
80.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
93
serum non-albumin protein measurement
2
84.7
blood metabolite measurement
2
83
0
1.1
82.8
childhood onset asthma
0
1.1
80.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 21
VGNC:10904
469556
Macaque
ubiquitin specific peptidase 21
719894
Mouse
MGI:1353665
30941
Rat
RGD:1588822
688466
Dog
ubiquitin specific peptidase 21
VGNC:53133
478979
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 21
Macaque
ubiquitin specific peptidase 21
Mouse
Rat
Dog
ubiquitin specific peptidase 21
Publication Statistics
PubMed Score 10.76
PubMed score by year
PubTator Score 44.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title