Tbio FAM208A Protein TASOR

Protein Summary

Description

Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3.

Uniprot Accession IDs

• Q9UK61
• A1L3A4
• B5ME28
• Q9H2F7
• Q9UPP7

Gene Name

• FAM208A

Ensembl ID

• ENST00000355628
• ENSP00000347845
• ENSG00000163946
• ENST00000431842
• ENSP00000399410
• ENST00000493960
• ENSP00000417509

Symbol

• C3orf63
• KIAA1105
• TASOR
• RAP140
• TASOR1
• se89-1
• C3orf63
• FAM208A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
histone modification site profile	0.81
microRNA	0.79
disease perturbation	0.74
tissue	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.78   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.78   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0