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Tbio
CCNL1
Cyclin-L1

Protein Summary
Description
Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295925
  • ENSP00000295925
  • ENSG00000163660
  • ENST00000295926
  • ENSP00000295926
  • ENST00000461804
  • ENSP00000420277
  • ENST00000465947
  • ENSP00000418094
  • ENST00000470121
  • ENSP00000417237
  • ENST00000475298
  • ENSP00000417343
  • ENST00000477127
  • ENSP00000418449
  • ENST00000631619
  • ENSP00000487951

Symbol
  • ANIA6A
  • BM-001
  • PRO1073
  • ania-6a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.99
virus perturbation
0.99
drug perturbation
0.96
transcription factor perturbation
0.8
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (80)
1 – 10 of 80
CDK11A
Tchem
Family: Kinase
Novelty: 0.02312993
p_int: 1
Score: 0.821
Data Source: BioPlex,STRINGDB
CDK11B
Tchem
Family: Kinase
Novelty: 0.02711308
p_int: 0.99999997
p_ni: 3e-8
Score: 0.727
Data Source: BioPlex,STRINGDB
SAP30BP
Tbio
Novelty: 0.12160951
p_int: 0.999284845
p_ni: 0.000715155
Score: 0.219
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.997521239
p_ni: 1.59e-7
p_wrong: 0.002478602
Score: 0.188
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.912665123
p_ni: 0.087334877
Score: 0.46
Data Source: BioPlex,STRINGDB
MCM2
Tbio
Novelty: 0.00276275
Score: 0.993
Data Source: STRINGDB
CDK4
Tclin
Family: Kinase
Novelty: 0.00036742
Score: 0.949
Data Source: STRINGDB
CDK6
Tclin
Family: Kinase
Novelty: 0.00109319
Score: 0.933
Data Source: STRINGDB
CDK12
Tchem
Family: Kinase
Novelty: 0.0119925
Score: 0.902
Data Source: STRINGDB
CCNB2
Tbio
Novelty: 0.00672914
Score: 0.889
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.69

PubMed score by year
PubTator Score  18.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer