SERPINA10
Protein Z-dependent protease inhibitor
Protein Summary
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors. The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
- ENST00000261994
- ENSP00000261994
- ENSG00000140093
- ENST00000393096
- ENSP00000376809
- ENST00000554173
- ENSP00000450971
- ENST00000614630
- ENSP00000484632
- ENSG00000278767
- ZPI
- PZI
- ZPI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.73 | ||
microRNA | 0.68 | ||
molecular function | 0.56 | ||
cell line | 0.54 | ||
cell type or tissue | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.37 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 304 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 105.37 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 304 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0