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Tbio
SERPINA10
Protein Z-dependent protease inhibitor

Protein Summary
Description
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors. The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261994
  • ENSP00000261994
  • ENSG00000140093
  • ENST00000393096
  • ENSP00000376809
  • ENST00000554173
  • ENSP00000450971
  • ENST00000614630
  • ENSP00000484632
  • ENSG00000278767

Symbol
  • ZPI
  • PZI
  • ZPI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
microRNA
0.68
molecular function
0.56
cell line
0.54
cell type or tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.97   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.97   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (90)
Items per page:
1 – 5 of 90
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
8
8
99.5
serum albumin measurement
1
8
8
99.5
sex hormone-binding globulin measurement
6
3
13
98
sex hormone-binding globulin measurement
6
3
13
98
testosterone measurement
6
4
10
97.6
Items per page:
1 – 5 of 90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
8
99.5
serum albumin measurement
8
99.5
sex hormone-binding globulin measurement
13
98
sex hormone-binding globulin measurement
13
98
testosterone measurement
10
97.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 10
VGNC:12528
453130
Macaque
serpin family A member 10
700874
Mouse
MGI:2667725
217847
Rat
RGD:6503444
100909524
Horse
serpin family A member 10
VGNC:22843
100064976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 10
Macaque
serpin family A member 10
Mouse
Rat
Horse
serpin family A member 10
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UK55-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (185)
1 – 10 of 185
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
p_int:  0.994794209
p_ni:  0.005205791
Score:  0.373
Data Source:  BioPlex,STRINGDB
MIA3
Tbio
Novelty:  0.02784348
p_int:  0.949336878
p_ni:  0.050663122
Score:  0.97
Data Source:  BioPlex,STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.945434666
p_ni:  0.054565308
p_wrong:  2.7e-8
Score:  0.534
Data Source:  BioPlex,STRINGDB
RGS2
Tbio
Novelty:  0.00370571
p_int:  0.817881597
p_ni:  0.182118403
Score:  0.209
Data Source:  BioPlex,STRINGDB
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
Score:  0.992
Data Source:  STRINGDB
ITIH2
Tbio
Novelty:  0.04886358
Score:  0.979
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.978
Data Source:  STRINGDB
PROC
Tchem
Family:  Enzyme
Novelty:  0.00440723
Score:  0.97
Data Source:  STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.97
Data Source:  STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.968
Data Source:  STRINGDB
Publication Statistics
PubMed Score  84.97

PubMed score by year
PubTator Score  49.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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