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Tbio
VPS28
Vacuolar protein sorting-associated protein 28 homolog

Protein Summary
Description
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292510
  • ENSP00000292510
  • ENSG00000160948
  • ENST00000377348
  • ENSP00000366565
  • ENST00000526054
  • ENSP00000434064
  • ENST00000529182
  • ENSP00000434556
  • ENST00000642202
  • ENSP00000494521
  • ENSG00000285339
  • ENST00000642867
  • ENSP00000496519
  • ENST00000643186
  • ENSP00000496693
  • ENST00000646588
  • ENSP00000495408
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
kinase perturbation
0.97
virus perturbation
0.92
histone modification site profile
0.91
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.5   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.5   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (15)
Assembly Of The HIV Virion (R-HSA-175474)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly Of The HIV Virion
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Assembly Of The HIV Virion
Autophagy
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (21)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (101)
1 – 10 of 101
UBAP1
Tbio
Novelty: 0.00564244
p_int: 1
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
VPS37A
Tbio
Novelty: 0.12564317
p_int: 0.999999958
p_ni: 4.1e-8
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VPS37D
Tdark
Novelty: 3.21428571
p_int: 0.999999844
p_ni: 1.56e-7
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
MVB12A
Tbio
Novelty: 0.01270321
p_int: 0.999999039
p_ni: 9.61e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
VPS37B
Tbio
Novelty: 0.39431873
p_int: 0.99999857
p_ni: 6.2e-8
p_wrong: 0.000001369
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MVB12B
Tbio
Novelty: 0.07628042
p_int: 0.999975278
p_ni: 0.000018769
p_wrong: 0.000005954
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
CYP2J2
Tchem
Novelty: 0.00634057
p_int: 0.999017469
p_ni: 0.000970666
p_wrong: 0.000011865
Data Source: BioPlex
SCN2B
Tbio
Family: IC
Novelty: 0.04179386
p_int: 0.998640868
p_ni: 0.001359115
p_wrong: 1.7e-8
Data Source: BioPlex
GRB2
Tchem
Novelty: 0.00060543
p_int: 0.998150714
p_ni: 0.001849245
p_wrong: 4.1e-8
Score: 0.184
Data Source: BioPlex,STRINGDB
SETX
Tbio
Family: Enzyme
Novelty: 0.00485793
p_int: 0.996676063
p_ni: 0.003323936
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  18.50

PubMed score by year
PubTator Score  12.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer