VPS28
Vacuolar protein sorting-associated protein 28 homolog
Protein Summary
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
- ENST00000292510
- ENSP00000292510
- ENSG00000160948
- ENST00000377348
- ENSP00000366565
- ENST00000526054
- ENSP00000434064
- ENST00000529182
- ENSP00000434556
- ENST00000642202
- ENSP00000494521
- ENSG00000285339
- ENST00000642867
- ENSP00000496519
- ENST00000643186
- ENSP00000496693
- ENST00000646588
- ENSP00000495408
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.97 | ||
kinase perturbation | 0.97 | ||
virus perturbation | 0.92 | ||
histone modification site profile | 0.91 | ||
disease perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.6 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 175 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.6 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 175 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0