Tbio ZNF580 Zinc finger protein 580

Protein Summary

Description

Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q9UK33
• B2RC05
• Q9NPP7

Gene Name

• ZNF580

Ensembl ID

• ENST00000325333
• ENSP00000320050
• ENSG00000213015
• ENST00000543039
• ENSP00000443957
• ENST00000545125
• ENSP00000446126

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.78
transcription factor binding site profile	0.66
gene perturbation	0.59
histone modification site profile	0.59
transcription factor	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.02   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.02   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0