You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ZNF580
Zinc finger protein 580

Protein Summary
Description
Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325333
  • ENSP00000320050
  • ENSG00000213015
  • ENST00000543039
  • ENSP00000443957
  • ENST00000545125
  • ENSP00000446126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.78
transcription factor binding site profile
0.66
gene perturbation
0.59
histone modification site profile
0.59
transcription factor
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (8)
PPP2R3A
Tbio
Family:  Enzyme
Novelty:  0.0350873
p_int:  0.983832056
p_wrong:  0.016167944
Score:  0.403
Data Source:  BioPlex,STRINGDB
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
Score:  0.53
Data Source:  STRINGDB
CAMK1G
Tchem
Family:  Kinase
Novelty:  0.12524578
Score:  0.483
Data Source:  STRINGDB
ZFHX2
Tdark
Family:  TF
Novelty:  0.36674507
Score:  0.48
Data Source:  STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
Score:  0.457
Data Source:  STRINGDB
SLC24A3
Tbio
Family:  Transporter
Novelty:  0.05923224
Score:  0.45
Data Source:  STRINGDB
CACNG3
Tbio
Family:  IC
Novelty:  0.32654561
Score:  0.448
Data Source:  STRINGDB
SCGN
Tbio
Novelty:  0.01434518
Score:  0.443
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
72.7
insomnia measurement
1
2
0
1.1
56.3
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
72.7
insomnia measurement
0
1.1
56.3
high density lipoprotein cholesterol measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 580
737441
Mouse
MGI:1916242
68992
Rat
RGD:1306892
308336
Dog
zinc finger protein 580
VGNC:48764
100688358
Cow
zinc finger protein 580
VGNC:52280
507619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 580
Mouse
Rat
Dog
zinc finger protein 580
Cow
zinc finger protein 580
Publication Statistics
PubMed Score 29.61
PubMed score by year
PubTator Score 8.78
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title