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Tchem
RPS6KA6
Ribosomal protein S6 kinase alpha-6

Protein Summary
Description
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262752
  • ENSP00000262752
  • ENSG00000072133
  • ENST00000620340
  • ENSP00000483896

Symbol
  • RSK4
  • RSK4
  • RSK-4
  • p90RSK6
  • PP90RSK4
  • S6K-alpha-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.95
interacting protein
0.78
microRNA
0.75
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.05   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.05   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (71)
OSGIN1
Tbio
Novelty:  0.03909733
p_int:  0.999998578
p_ni:  2.9e-8
p_wrong:  0.000001393
Score:  0.692
Data Source:  BioPlex,STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.976
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.953
Data Source:  STRINGDB
PDPK1
Tchem
Family:  Kinase
Novelty:  0.00430458
Score:  0.939
Data Source:  STRINGDB
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.918
Data Source:  STRINGDB
RPS6KA3
Tchem
Family:  Kinase
Novelty:  0.00221219
Score:  0.912
Data Source:  STRINGDB
RPS6KA5
Tchem
Family:  Kinase
Novelty:  0.00811496
Score:  0.907
Data Source:  STRINGDB
RPS6KA4
Tchem
Family:  Kinase
Novelty:  0.05213255
Score:  0.905
Data Source:  STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
Score:  0.902
Data Source:  STRINGDB
RPS6KA2
Tchem
Family:  Kinase
Novelty:  0.00409407
Score:  0.901
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (33)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Axon guidance
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Developmental Biology
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Axon guidance
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Developmental Biology
L1CAM interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
0.8
dentures
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
0.8
dentures
1
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase A6
VGNC:13433
743327
Macaque
ribosomal protein S6 kinase A6
710337
Mouse
MGI:1914321
67071
Rat
RGD:1560817
317203
Dog
ribosomal protein S6 kinase A6
VGNC:45743
491989
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase A6
Macaque
ribosomal protein S6 kinase A6
Mouse
Rat
Dog
ribosomal protein S6 kinase A6
Publication Statistics
PubMed Score 39.05
PubMed score by year
PubTator Score 24.50
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title