RPS6KA6
Ribosomal protein S6 kinase alpha-6
Protein Summary
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
- ENST00000262752
- ENSP00000262752
- ENSG00000072133
- ENST00000620340
- ENSP00000483896
- RSK4
- RSK4
- RSK-4
- p90RSK6
- PP90RSK4
- S6K-alpha-6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.95 | ||
interacting protein | 0.78 | ||
microRNA | 0.75 | ||
biological process | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.39 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 220 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.39 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 220 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 18
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0